| Gene Symbol | RORB |
|---|---|
| Entrez Gene | 6096 |
| Alt Symbol | NR1F2, ROR-BETA, RZR-BETA, RZRB, bA133M9.1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | RAR-related orphan receptor B |
| Other Description | RAR-related orphan receptor beta|nuclear receptor ROR-beta|nuclear receptor RZR-beta|nuclear receptor subfamily 1 group F member 2|retinoic acid-binding receptor beta|retinoid-related orphan receptor beta|retinoid-related orphan receptor-beta |
| Swissprots | Q92753 Q8WX73 |
| Accessions | EAW62552 Q92753 AB307695 BAH02286 AK313431 BAG36222 AL118995 AL691650 BC051830 AAH51830 BC093772 AAH93772 BC093774 AAH93774 BM669680 BM698896 BX647070 EU446652 ABZ92181 HQ709186 ADZ17393 Y08639 CAA69929 NM_006914 NP_008845 |
| Function | Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiatio |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}. |
| Top Pathways | Circadian rhythm |