| Gene Symbol |
Mzb1
|
| Entrez Gene |
69816
|
| Alt Symbol |
2010001M09Rik, AV064572, PACAP, pERp1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
marginal zone B and B1 cell-specific protein 1
|
| Other Description |
marginal zone B- and B1-cell-specific protein|plasma cell-induced ER protein 1|plasma cell-induced resident ER protein|plasma cell-induced resident endoplasmic reticulum protein|proapoptotic caspase adapter protein
|
| Swissprots |
Q9D8I1 Q8K2M5 D2IYS1 Q8BU13 Q6P3D3
|
| Accessions |
CAH19023 CAH25960 EDK97136 EDK97137 Q9D8I1 AA866731 AK008016 BAB25410 AK088094 BAC40141 BC030674 AAH30674 BC064044 AAH64044 GQ477351 ACY74344 NM_027222 NP_081498
|
| Function |
Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation.
|
| Subcellular Location |
Endoplasmic reticulum. Endoplasmic reticulum lumen. Secreted.
|
| Tissue Specificity |
Expressed predominantly in the spleen and lymph nodes. Abundantly expressed in marginal zone B and B1 cells. High expression in mesenteric adipose tissue (MAT). Expressed also in pancreas, perigonadal adipose tissue (PAT), uterus, subcutaneous adipose tissue, heart, muscle, ovary and liver. Very low expression is detected in brown adipose tissue. In PAT, significantly higher expression in stromal-vascular cell than in adipocytes. Expressed in macrophage RAW 264.7 cell line. Down- regulated in For-knockout female MAT at 5 months (obese state) followed by steep up-regulation at 9 months (prediabetic condition) when mutants progress towards the metabolic syndrome. {ECO:0000269|PubMed:19805154, ECO:0000269|PubMed:21093319, ECO:0000269|PubMed:21688198}.
|