| Gene Symbol |
MFGE8
|
| Entrez Gene |
4240
|
| Alt Symbol |
BA46, EDIL1, HMFG, HsT19888, MFG-E8, MFGM, OAcGD3S, SED1, SPAG10, hP47
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
milk fat globule-EGF factor 8 protein
|
| Other Description |
O-acetyl disialoganglioside synthase|breast epithelial antigen BA46|lactadherin|medin|sperm associated antigen 10|sperm surface protein hP47
|
| Swissprots |
Q7Z3D2 Q53FU9 B2R6M7 Q08431 Q9BTL9
|
| Accessions |
EAX02025 EAX02026 EAX02027 EAX02028 EAX02029 EAX02030 Q08431 AK095908 BAG53164 AK222735 BAD96455 AK223182 BAD96902 AK304627 BAG65408 AK310357 AK312640 BAG35524 AU134066 AY141974 AAN08508 BC003610 AAH03610 BT006948 AAP35594 BU726667 BX537974 CAD97938 EU832670 ACE87761 EU832749 ACE87081 S56151 AAB19771 U58516 AAC50549 XM_005254921 XP_005254978 XR_931838 NM_001114614 NP_001108086 NM_005928 NP_005919
|
| Function |
Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication. {ECO:0000250, ECO:0000269|PubMed:19204935}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:19204935}; Peripheral membrane protein {ECO:0000269|PubMed:19204935}. Secreted {ECO:0000269|PubMed:19204935}.
|
| Tissue Specificity |
Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas.
|
![Western Blot: Milk Fat Globule 1 Overexpression Lysate (Adult Normal) [NBL1-13037] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Milk Fat Globule 1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4656_Milk%2520Fat%2520Globule%25201%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13037-img0002.jpg)