| Gene Symbol |
ZDHHC21
|
| Entrez Gene |
340481
|
| Alt Symbol |
9130404H11Rik, DHHC-21, DHHC21, DNZ1, HSPC097
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger, DHHC-type containing 21
|
| Other Description |
palmitoyltransferase ZDHHC21|probable palmitoyltransferase ZDHHC21|zinc finger DHHC domain-containing protein 21|zinc finger, DHHC domain containing 21
|
| Swissprots |
D3DRI7 Q5VWG1 A8KA95 Q8IVQ6
|
| Accessions |
EAW58692 EAW58693 Q8IVQ6 AF161360 AAF28920 AK026322 AK096860 AK124263 AK127313 AK292960 BAF85649 BC042439 BC042558 AAH42558 HQ447981 ADQ32464 XM_006716760 XP_006716823 XM_011517851 XP_011516153 XM_011517852 XP_011516154 XM_011517853 XP_011516155 XM_011517854 XP_011516156 XM_011517855 XP_011516157 NM_178566 NP_848661
|
| Function |
Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus {ECO:0000250}.
|
![Western Blot: ZDHHC21 Overexpression Lysate (Adult Normal) [NBP2-04950] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ZDHHC21.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/24095_ZDHHC21%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-04950-img0001.jpg)