F2RL1

Gene Symbol	F2RL1
Entrez Gene	2150
Alt Symbol	GPR11, PAR2
Species	Human
Gene Type	protein-coding
Description	coagulation factor II (thrombin) receptor-like 1
Other Description	G-protein coupled receptor 11|coagulation factor II receptor-like 1|protease-activated receptor 2|proteinase-activated receptor 2|thrombin receptor-like 1
Swissprots	Q13317 Q53XJ8 Q13346 P55085
Accessions	AAA90957 AAK77914 CAA90290 CAV28807 EAW95782 P55085 AY336105 AAP97012 BC012453 AAH12453 BC018130 AAH18130 BT009856 AAP88858 DB463838 DQ890966 ABM81892 DQ894139 ABM85065 U34038 AAB47871 U67058 NM_005242 NP_005233
Function	Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I- kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion. Involved in the regulation of vascular tone; activation results in hypotension presumab
Subcellular Location	Cell membrane; Multi-pass membrane protein.
Tissue Specificity	Widely expressed in tissues with especially high levels in pancreas, liver, kidney, small intestine, and colon. Moderate expression is detected in many organs, but none in brain or skeletal muscle.
Top Pathways	African trypanosomiasis, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse F2RL1 / PAR2 ELISA Kit (Sandwich ELISA) - LS-F4277 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 0.053 ng/ml Range 0.156-10 ng/ml

Rat F2RL1 / PAR2 ELISA Kit (Sandwich ELISA) - LS-F4276 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.053 ng/ml Range 0.156-10 ng/ml

Human F2RL1 / PAR2 ELISA Kit (Sandwich ELISA) - LS-F5365 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Human F2RL1 / PAR2 ELISA Kit (Sandwich ELISA) - LS-F12260 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.156-10 ng/ml

Human PAR2 ELISA Kit - abx152639 from Abbexa Category ELISA Kit Sensitivity 0.059 ng/ml Range 0.156 ng/ml - 10 ng/ml

Protease Activated Receptor 2, PAR2, Human, ELISA Kit - E-EL-H1200 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Protease Activated Receptor 2 (PAR2), Human, ELISA Kit - SEA852Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.053ng/mL Range 0.156-10ng/mL

Proteinase-activated receptor 2, F2RL1, Human, ELISA Kit - E2022h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Protease Activated Receptor 2, PAR2, Mouse, ELISA Kit - E-EL-M0963 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Protease Activated Receptor 2, PAR2, Rat, ELISA Kit - E-EL-R0798 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 4.688 Range 7.813-500nIU/mL

Protease Activated Receptor 2, PAR2, Rabbit, ELISA Kit - E-EL-RB1298 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Protease Activated Receptor 2, PAR2, Chicken, ELISA Kit - E-EL-Ch1774 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Protease Activated Receptor 2, PAR2, Porcine, ELISA Kit - E-EL-P2147 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Protease Activated Receptor 2, PAR2, Sheep, ELISA Kit - E-EL-S0317 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Protease Activated Receptor 2, PAR2, Guinea Pig, ELISA Kit - E-EL-GP0214 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Protease Activated Receptor 2, PAR2, Monkey, ELISA Kit - E-EL-MK0269 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Protease Activated Receptor 2 (PAR2), Human, CLIA Kit - SCA852Hu from ARP American Research Products Category CLIA Kit Prices $840.00 Sizes 96 t Sensitivity 0.058ng/mL Range 0.156-10ng/mL

Human PAR2 ELISA Kit - HP0067 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine PAR2 ELISA Kit - AP0067 from NeoScientific Category ELISA Kit Prices $300.00, $480.00 Sizes 100 µl, 200 µl

Proteinase-activated receptor 2, ELISA Kit - MBS281836 from MyBioSource Category ELISA Kit Prices $425.00, $720.00, $3,160.00, $6,055.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human PAR2(Protease Activated Receptor 2) ELISA Kit - E-EL-H1200 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Human PAR2 (Protease Activated Receptor 2) CLIA Kit - E-CL-H0783 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

PAR2, ELISA Kit - MBS2513205 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

PAR2, ELISA Kit - MBS2501440 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.469ng/mL Range 0.781-50ng/mL

PAR2, ELISA Kit - MBS2504272 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156--10ng/mL

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