F2RL1
| Gene Symbol | F2RL1 |
|---|---|
| Entrez Gene | 2150 |
| Alt Symbol | GPR11, PAR2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | coagulation factor II (thrombin) receptor-like 1 |
| Other Description | G-protein coupled receptor 11|coagulation factor II receptor-like 1|protease-activated receptor 2|proteinase-activated receptor 2|thrombin receptor-like 1 |
| Swissprots | Q13317 Q53XJ8 Q13346 P55085 |
| Accessions | AAA90957 AAK77914 CAA90290 CAV28807 EAW95782 P55085 AY336105 AAP97012 BC012453 AAH12453 BC018130 AAH18130 BT009856 AAP88858 DB463838 DQ890966 ABM81892 DQ894139 ABM85065 U34038 AAB47871 U67058 NM_005242 NP_005233 |
| Function | Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I- kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion. Involved in the regulation of vascular tone; activation results in hypotension presumab |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Widely expressed in tissues with especially high levels in pancreas, liver, kidney, small intestine, and colon. Moderate expression is detected in many organs, but none in brain or skeletal muscle. |
| Top Pathways | African trypanosomiasis, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction |
PAR-2 CRISPR/Cas9 KO Plasmid (h) - sc-400333 from Santa Cruz Biotechnology
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PAR-2 HDR Plasmid (h) - sc-400333-HDR from Santa Cruz Biotechnology
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PAR-2 Double Nickase Plasmid (h) - sc-400333-NIC from Santa Cruz Biotechnology
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PAR-2 Double Nickase Plasmid (h2) - sc-400333-NIC-2 from Santa Cruz Biotechnology
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PAR-2 CRISPR Activation Plasmid (h) - sc-400333-ACT from Santa Cruz Biotechnology
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PAR-2 CRISPR Activation Plasmid (h2) - sc-400333-ACT-2 from Santa Cruz Biotechnology
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PAR-2 Lentiviral Activation Particles (h) - sc-400333-LAC from Santa Cruz Biotechnology
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PAR-2 Lentiviral Activation Particles (h2) - sc-400333-LAC-2 from Santa Cruz Biotechnology
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PAR-2 siRNA (h) - sc-36188 from Santa Cruz Biotechnology
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PAR-2 shRNA Plasmid (h) - sc-36188-SH from Santa Cruz Biotechnology
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PAR-2 shRNA (h) Lentiviral Particles - sc-36188-V from Santa Cruz Biotechnology
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PAR2 RNAi - H00002150-R02 from Novus Biologicals
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MISSION® esiRNA - EHU057201 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2278 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2278 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09759 from Sigma-Aldrich
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F2RL1 siRNA (Human) - CRH1494 from Cohesion Biosciences
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F2RL1 - MBS829287 from MyBioSource
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shRNA set against Human F2RL1 (NM_005242.4) - SHH288453 from Creative biogene
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Human F2RL1 siRNA - orb261996 from Biorbyt
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F2RL1 shRNA Plasmid (Human) - CHH1494 from Cohesion Biosciences
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F2RL1 miRNA 3'UTR clone - MiUTR3H-03745 from Creative biogene
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