| Gene Symbol | F2RL1 |
|---|---|
| Entrez Gene | 2150 |
| Alt Symbol | GPR11, PAR2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | coagulation factor II (thrombin) receptor-like 1 |
| Other Description | G-protein coupled receptor 11|coagulation factor II receptor-like 1|protease-activated receptor 2|proteinase-activated receptor 2|thrombin receptor-like 1 |
| Swissprots | Q13317 Q53XJ8 Q13346 P55085 |
| Accessions | AAA90957 AAK77914 CAA90290 CAV28807 EAW95782 P55085 AY336105 AAP97012 BC012453 AAH12453 BC018130 AAH18130 BT009856 AAP88858 DB463838 DQ890966 ABM81892 DQ894139 ABM85065 U34038 AAB47871 U67058 NM_005242 NP_005233 |
| Function | Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I- kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion. Involved in the regulation of vascular tone; activation results in hypotension presumab |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Widely expressed in tissues with especially high levels in pancreas, liver, kidney, small intestine, and colon. Moderate expression is detected in many organs, but none in brain or skeletal muscle. |
| Top Pathways | African trypanosomiasis, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction |