Gene Symbol | SLN |
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Entrez Gene | 6588 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | sarcolipin |
Other Description | - |
Swissprots | Q6ICV3 O00631 |
Accessions | AAB86980 EAW67094 O00631 AK312097 BAG35033 BC005261 AAH05261 BC094685 AAH94685 BC104150 AAI04151 BC104185 AAI04186 BC113930 AAI13931 BC113987 AAI13988 BP233121 CR450290 CAG29286 F30315 U96094 AAB86981 NM_003063 NP_003054 |
Function | Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Required for muscle-based, non-shivering thermogenesis (By similarity). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. {ECO:0000250, ECO:0000269|PubMed:11781085, ECO:0000269|PubMed:9575189}. |
Subcellular Location | Sarcoplasmic reticulum membrane; Single-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. |
SLN CRISPR/Cas9 KO Plasmid (h) - sc-416898 from Santa Cruz Biotechnology
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SLN HDR Plasmid (h) - sc-416898-HDR from Santa Cruz Biotechnology
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SLN Double Nickase Plasmid (h) - sc-416898-NIC from Santa Cruz Biotechnology
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SLN Double Nickase Plasmid (h2) - sc-416898-NIC-2 from Santa Cruz Biotechnology
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SLN CRISPR Activation Plasmid (h) - sc-416898-ACT from Santa Cruz Biotechnology
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SLN CRISPR Activation Plasmid (h2) - sc-416898-ACT-2 from Santa Cruz Biotechnology
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SLN Lentiviral Activation Particles (h) - sc-416898-LAC from Santa Cruz Biotechnology
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SLN Lentiviral Activation Particles (h2) - sc-416898-LAC-2 from Santa Cruz Biotechnology
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SLN siRNA (h) - sc-45593 from Santa Cruz Biotechnology
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SLN shRNA Plasmid (h) - sc-45593-SH from Santa Cruz Biotechnology
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SLN shRNA (h) Lentiviral Particles - sc-45593-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU130691 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19739 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19739 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05460 from Sigma-Aldrich
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SLN siRNA (Human) - CRH4475 from Cohesion Biosciences
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SLN - MBS8225322 from MyBioSource
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shRNA set against Human SLN (NM_003063.2) - SHH412832 from Creative biogene
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shRNA set against Human SLN(NM_003063.2) - SHL014662 from Creative biogene
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Human SLN siRNA - orb264977 from Biorbyt
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SLN shRNA Plasmid (Human) - CHH4475 from Cohesion Biosciences
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SLN miRNA 3'UTR clone - MiUTR1H-09628 from Creative biogene
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