| Gene Symbol |
RDH8
|
| Entrez Gene |
50700
|
| Alt Symbol |
PRRDH, SDR28C2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
retinol dehydrogenase 8 (all-trans)
|
| Other Description |
photoreceptor outer segment all-trans retinol dehydrogenase|retinol dehydrogenase 8|short chain dehydrogenase/reductase family 28C member 2|short chain dehydrogenase/reductase family 28C, member 2
|
| Swissprots |
Q9NYR8 Q9H838
|
| Accessions |
EAW84062 Q9NYR8 AF229845 AAF63160 AK024022 BAB14782 BC140328 AAI40329 BC146479 AAI46480 DQ426888 NM_015725 NP_056540
|
| Function |
Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Detected in photoreceptor outer segments in the retina (at protein level). {ECO:0000269|PubMed:10753906}.
|
| Top Pathways |
Retinol metabolism
|
![Western Blot: retinol dehydrogenase 8 (all trans) Overexpression Lysate (Adult Normal) [NBP2-07124] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for retinol dehydrogenase 8 (all trans).](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9844_retinol%2520dehydrogenase%25208%2520(all%2520trans)%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07124-img0001.jpg)