Gene Symbol | RDH8 |
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Entrez Gene | 50700 |
Alt Symbol | PRRDH, SDR28C2 |
Species | Human |
Gene Type | protein-coding |
Description | retinol dehydrogenase 8 (all-trans) |
Other Description | photoreceptor outer segment all-trans retinol dehydrogenase|retinol dehydrogenase 8|short chain dehydrogenase/reductase family 28C member 2|short chain dehydrogenase/reductase family 28C, member 2 |
Swissprots | Q9NYR8 Q9H838 |
Accessions | EAW84062 Q9NYR8 AF229845 AAF63160 AK024022 BAB14782 BC140328 AAI40329 BC146479 AAI46480 DQ426888 NM_015725 NP_056540 |
Function | Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity (By similarity). {ECO:0000250}. |
Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Detected in photoreceptor outer segments in the retina (at protein level). {ECO:0000269|PubMed:10753906}. |
Top Pathways | Retinol metabolism |
RDH8 CRISPR/Cas9 KO Plasmid (h) - sc-408441 from Santa Cruz Biotechnology
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RDH8 HDR Plasmid (h) - sc-408441-HDR from Santa Cruz Biotechnology
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RDH8 Double Nickase Plasmid (h) - sc-408441-NIC from Santa Cruz Biotechnology
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RDH8 Double Nickase Plasmid (h2) - sc-408441-NIC-2 from Santa Cruz Biotechnology
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RDH8 CRISPR Activation Plasmid (h) - sc-408441-ACT from Santa Cruz Biotechnology
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RDH8 CRISPR Activation Plasmid (h2) - sc-408441-ACT-2 from Santa Cruz Biotechnology
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RDH8 Lentiviral Activation Particles (h) - sc-408441-LAC from Santa Cruz Biotechnology
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RDH8 Lentiviral Activation Particles (h2) - sc-408441-LAC-2 from Santa Cruz Biotechnology
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RDH8 siRNA (h) - sc-97854 from Santa Cruz Biotechnology
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RDH8 shRNA Plasmid (h) - sc-97854-SH from Santa Cruz Biotechnology
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RDH8 shRNA (h) Lentiviral Particles - sc-97854-V from Santa Cruz Biotechnology
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retinol dehydrogenase 8 (all trans) RNAi - H00050700-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN18115 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18115 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05041 from Sigma-Aldrich
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RDH8 siRNA (Human) - CRH9401 from Cohesion Biosciences
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RDH8 - MBS8200838 from MyBioSource
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shRNA set against Human RDH8 (NM_015725.2) - SHH391536 from Creative biogene
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shRNA set against Human RDH8(NM_015725.2) - SHR174388 from Creative biogene
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RDH8 shRNA Plasmid (Human) - CHH9401 from Cohesion Biosciences
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RDH8 miRNA 3'UTR clone - MiUTR1H-08720 from Creative biogene
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