Gene Symbol | UROS |
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Entrez Gene | 7390 |
Alt Symbol | UROIIIS |
Species | Human |
Gene Type | protein-coding |
Description | uroporphyrinogen III synthase |
Other Description | hydroxymethylbilane hydrolyase|uroporphyrinogen-III cosynthase|uroporphyrinogen-III synthase |
Swissprots | B2RC13 Q9H2T1 P10746 D3DRF7 |
Accessions | EAW49221 EAW49222 EAW49223 EAW49224 EAW49225 EAW49226 EAW49227 EAW49228 EAW49229 P10746 AF230665 AAG36795 AK314896 BAG37410 BC002573 AAH02573 BC004338 AAH04338 DQ891936 ABM82862 DQ895123 ABM86049 DR156879 J03824 AAA60273 XM_005270137 XP_005270194 XM_005270138 XP_005270195 XM_005270139 XP_005270196 XM_005270140 XP_005270197 XM_005270141 XP_005270198 XM_006717960 XP_006718023 XM_011540126 XP_011538428 XM_011540127 XP_011538429 XR_246103 XR_945809 XR_945810 NM_000375 NP_000366 |
Function | Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme). |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:11112350}. |
Top Pathways | Porphyrin and chlorophyll metabolism |
UROS (A-8) - sc-365877 from Santa Cruz Biotechnology
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UROS (C-16) - sc-49568 from Santa Cruz Biotechnology
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UROS (G-9) - sc-365120 from Santa Cruz Biotechnology
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UROS (N-20) - sc-49570 from Santa Cruz Biotechnology
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Anti-UROS antibody - ab95082 from Abcam
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Anti-UROS antibody - ab58097 from Abcam
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Anti-UROS antibody - ab172075 from Abcam
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Anti-UROS Antibody (aa1-266, Azide-free) - LS-C329035 from LifeSpan Bioscience
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Anti-UROS Antibody (clone 1E11-B11) - LS-C198415 from LifeSpan Bioscience
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UROS Antibody - NBP1-92565 from Novus Biologicals
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UROS Antibody - H00007390-D01P from Novus Biologicals
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UROS Antibody (1E11-B11) - H00007390-M01 from Novus Biologicals
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UROS Antibody - NBP1-32485 from Novus Biologicals
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UROS Antibody - H00007390-B01P from Novus Biologicals
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UROS Antibody - H00007390-D01 from Novus Biologicals
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UROS Antibody - H00007390-A01 from Novus Biologicals
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Anti-UROS (176-189) antibody produced in rabbit - SAB1105490 from Sigma-Aldrich
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Monoclonal Anti-UROS antibody produced in mouse - WH0007390M1 from Sigma-Aldrich
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Anti-UROS antibody produced in rabbit - HPA044038 from Sigma-Aldrich
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Anti-UROS antibody produced in mouse - SAB1406573 from Sigma-Aldrich
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Anti-UROS antibody produced in rabbit - SAB1411388 from Sigma-Aldrich
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UROS-Antibody-monoclonal-M01 - AT4475a from Abgent, a WuXi AppTec company
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UROS antibody - 70R-21184 from Fitzgerald
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UROS antibody - 14913-1-AP from Acris Antibodies
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UROS antibody - H00007390-A01 from Acris Antibodies
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