| Gene Symbol | NDUFA1 |
|---|---|
| Entrez Gene | 4694 |
| Alt Symbol | CI-MWFE, MWFE, ZNF183 |
| Species | Human |
| Gene Type | protein-coding |
| Description | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa |
| Other Description | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1|NADH oxidoreductase subunit MWFE|NADH-ubiquinone oxidoreductase MWFE subunit|NADH:ubiquinone oxidoreductase (complex 1)|complex I MWFE subunit|complex I-MWFE|type I dehydrogenase |
| Swissprots | O15239 |
| Accessions | EAW89840 O15239 AB451304 BAG70118 AB451435 BAG70249 BC000266 AAH00266 BQ680674 CR456889 CAG33170 U54993 AAD00084 X81900 CAA57489 NM_004541 NP_004532 |
| Function | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. |
| Subcellular Location | Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. |
| Tissue Specificity | Primarily expressed in heart and skeletal muscle. |
| Top Pathways | Alzheimer's disease, Huntington's disease, Non-alcoholic fatty liver disease (NAFLD), Oxidative phosphorylation |