KCNK10

Gene Symbol KCNK10
Entrez Gene 54207
Alt Symbol K2p10.1, PPP1R97, TREK-2, TREK2
Species Human
Gene Type protein-coding
Description potassium channel, two pore domain subfamily K, member 10
Other Description 2P domain potassium channel TREK2|TREK-2 K(+) channel subunit|TWIK-related K+ channel 2|outward rectifying potassium channel protein TREK-2|potassium channel TREK-2|potassium channel subfamily K member 10|potassium channel, subfamily K, member 10|protein phosphatase 1, regulatory subunit 97
Swissprots B2RCT3 B2R8T4 Q9HB59 Q8TDK8 B5TJL4 Q6B014 P57789 Q8TDK7
Accessions EAW81373 EAW81374 EAW81375 P57789 AF279890 AAG15191 AF385399 AAL95705 AF385400 AAL95706 AI693366 AK125389 AK290518 BAF83207 AK313499 BAG36281 AK315263 BAG37680 BC075021 AAH75021 BC075022 AAH75022 EU978938 ACH86097 EU978939 ACH86098 EU978940 ACH86099 EU978941 ACH86100 U79244 XM_011536840 XP_011535142 NM_021161 NP_066984 NM_138317 NP_612190 NM_138318 NP_612191
Function Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain.
Top Pathways Gastric acid secretion

TREK-2 (C-20) - sc-69640 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TREK-2 (C-20): sc-69640. Western blot analysis of human recombinant TREK-2 fusion protein.

TREK-2 (E-19) - sc-69641 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TREK-2 (K-16) - sc-69642 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TREK-2 (S-14) - sc-11560 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TREK-2 (S-14): sc-11560. Western blot analysis of human recombinant TREK-2 fusion protein.

TREK-2 (H-180) - sc-98688 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

TREK-2 (F-21) - sc-134111 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
TREK-2 (F-21): sc-134111. Western blot analysis of TREK-2 expression in Jurkat whole cell lysate.

Anti-KCNK10 antibody - ab48868 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-KCNK10 antibody (ab48868) at 1.4 µg/ml (in 5% skimmed milk/PBS) + Jurkat cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-KCNK10 antibody - ab172571 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-KCNK10 antibody (ab172571) at 1 µg/mlLane 1 : KCNK10 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-KCNK10 antibody - ab48867 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-KCNK10 antibody (ab48867) at 2.5 µg/ml (in 5% skimmed milk/PBS buffer) + Jurkat cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-KCNK10 antibody - ab57259 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57259 KCNK10 antibody at 1ug/ml.

Anti-KCNK10 antibody - C-terminal - ab84210 from Abcam

Host Rabbit
Clonality Polyclonal
ICC/IF image of ab84210 stained HeLa cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab84210, 1/1000 dilution) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-KCNK10 / TREK Antibody (aa504-532) - LS-C165439 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
KCNK10 Antibody western blot of HepG2 cell line lysates (35 ug/lane). The KCNK10 antibody detected the KCNK10 protein (arrow).

Anti-KCNK10 / TREK Antibody (aa503-532, AP) - LS-C246808 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNK10 / TREK Antibody (aa503-532, FITC) - LS-C236749 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNK10 / TREK Antibody (aa503-532, PE) - LS-C236752 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNK10 / TREK Antibody (aa503-532, Biotin) - LS-C246810 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNK10 / TREK Antibody (aa503-532, APC) - LS-C246809 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNK10 / TREK Antibody (aa503-532, Azide-free, HRP) - LS-C249307 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNK10 / TREK Antibody (aa439-539) - LS-C309154 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-KCNK10 / TREK Antibody (aa503-532) - LS-C329720 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNK10 / TREK Antibody (aa467-516) - LS-C31691 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Jurkat Cell Lysate

Anti-KCNK10 / TREK Antibody (aa436-485) - LS-C31248 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Jurkat Cell Lysate

Anti-KCNK10 / TREK Antibody - LS-C309155 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-KCNK10 / TREK Antibody (aa72-121) - LS-C31690 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
HepG2 Cell Lysate

Anti-KCNK10 / TREK Antibody (aa108-157) - LS-C110034 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
KCNK10 antibody LS-C110034 Western blot of Fetal Brain lysate.
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