KCNK10
| Gene Symbol | KCNK10 |
|---|---|
| Entrez Gene | 54207 |
| Alt Symbol | K2p10.1, PPP1R97, TREK-2, TREK2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | potassium channel, two pore domain subfamily K, member 10 |
| Other Description | 2P domain potassium channel TREK2|TREK-2 K(+) channel subunit|TWIK-related K+ channel 2|outward rectifying potassium channel protein TREK-2|potassium channel TREK-2|potassium channel subfamily K member 10|potassium channel, subfamily K, member 10|protein phosphatase 1, regulatory subunit 97 |
| Swissprots | B2RCT3 B2R8T4 Q9HB59 Q8TDK8 B5TJL4 Q6B014 P57789 Q8TDK7 |
| Accessions | EAW81373 EAW81374 EAW81375 P57789 AF279890 AAG15191 AF385399 AAL95705 AF385400 AAL95706 AI693366 AK125389 AK290518 BAF83207 AK313499 BAG36281 AK315263 BAG37680 BC075021 AAH75021 BC075022 AAH75022 EU978938 ACH86097 EU978939 ACH86098 EU978940 ACH86099 EU978941 ACH86100 U79244 XM_011536840 XP_011535142 NM_021161 NP_066984 NM_138317 NP_612190 NM_138318 NP_612191 |
| Function | Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids. |
| Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Tissue Specificity | Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain. |
| Top Pathways | Gastric acid secretion |
TREK-2 CRISPR/Cas9 KO Plasmid (h) - sc-404062 from Santa Cruz Biotechnology
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TREK-2 HDR Plasmid (h) - sc-404062-HDR from Santa Cruz Biotechnology
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TREK-2 Double Nickase Plasmid (h) - sc-404062-NIC from Santa Cruz Biotechnology
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TREK-2 Double Nickase Plasmid (h2) - sc-404062-NIC-2 from Santa Cruz Biotechnology
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TREK-2 CRISPR Activation Plasmid (h) - sc-404062-ACT from Santa Cruz Biotechnology
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TREK-2 CRISPR Activation Plasmid (h2) - sc-404062-ACT-2 from Santa Cruz Biotechnology
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TREK-2 Lentiviral Activation Particles (h) - sc-404062-LAC from Santa Cruz Biotechnology
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TREK-2 Lentiviral Activation Particles (h2) - sc-404062-LAC-2 from Santa Cruz Biotechnology
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TREK-2 siRNA (h) - sc-42347 from Santa Cruz Biotechnology
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TREK-2 shRNA Plasmid (h) - sc-42347-SH from Santa Cruz Biotechnology
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TREK-2 shRNA (h) Lentiviral Particles - sc-42347-V from Santa Cruz Biotechnology
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KCNK10 RNAi - H00054207-R03 from Novus Biologicals
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KCNK10 RNAi - H00054207-R02 from Novus Biologicals
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KCNK10 RNAi - H00054207-R01 from Novus Biologicals
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MISSION® esiRNA - EHU091251 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10963 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10963 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05551 from Sigma-Aldrich
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KCNK10 siRNA (Human) - CRJ0031 from Cohesion Biosciences
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shRNA set against Human KCNK10 (NM_021161.4) - SHH323371 from Creative biogene
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Human KCNK10 siRNA - orb270532 from Biorbyt
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KCNK10 shRNA Plasmid (Human) - CHJ0031 from Cohesion Biosciences
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