| Gene Symbol | NUDC |
|---|---|
| Entrez Gene | 10726 |
| Alt Symbol | HNUDC, MNUDC, NPD011 |
| Species | Human |
| Gene Type | protein-coding |
| Description | nudC nuclear distribution protein |
| Other Description | nuclear distribution C homolog|nuclear distribution gene C homolog|nuclear distribution protein C homolog|nuclear migration protein nudC |
| Swissprots | Q9Y266 Q9H0N2 Q9Y2B6 Q5QP31 Q5QP35 |
| Accessions | EAX07780 Q9Y266 AB019408 BAA76628 AF086922 AAP97152 AF100760 AAD43024 AF125465 AAD39921 AF130736 AAD30517 AF241788 AAG44476 AL136725 CAB66659 AM392722 CAL37600 AM393251 CAL38129 BC002399 AAH02399 BC003132 AAH03132 BC006147 AAH06147 BC007280 AAH07280 BC015153 AAH15153 BC021139 AAH21139 BP348144 XM_011540529 XP_011538831 XM_011540530 XP_011538832 NM_006600 NP_006591 |
| Function | Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation. {ECO:0000250, ECO:0000269|PubMed:12679384, ECO:0000269|PubMed:12852857}. |
| Subcellular Location | Cytoplasm, cytoskeleton. Nucleus. Note=In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells. A small proportion is nuclear, in a punctate pattern. |
| Tissue Specificity | Ubiquitous. Highly expressed in fetal liver, kidney, lung and brain. Highly expressed in adult pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain and heart. {ECO:0000269|PubMed:10210332, ECO:0000269|PubMed:10453739}. |