PPP2R2B
| Gene Symbol | PPP2R2B |
|---|---|
| Entrez Gene | 5521 |
| Alt Symbol | B55BETA, PP2AB55BETA, PP2ABBETA, PP2APR55B, PP2APR55BETA, PR2AB55BETA, PR2ABBETA, PR2APR55BETA, PR52B, PR55-BETA, PR55BETA, SCA12 |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein phosphatase 2, regulatory subunit B, beta |
| Other Description | PP2A subunit B isoform B55-beta|PP2A subunit B isoform PR55-beta|PP2A subunit B isoform R2-beta|PP2A, subunit B, B-beta isoform|protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform|protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform|serine/threonine protein phosphatase 2A, 55 kDa regulatory subunit B, beta isoform|serine/threonine protein phosphatase 2A, neuronal isoform|serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform |
| Swissprots | D3DQF8 B7Z304 D3DQF7 A6NEJ2 A8K102 Q00005 B7Z2F2 B3KPD0 G3V149 |
| Accessions | AAF74024 EAW61829 EAW61830 EAW61831 EAW61832 EAW61833 EAW61834 EAW61835 Q00005 AI621232 AK056192 BAG51642 AK289717 BAF82406 AK294659 BAH11838 AK295347 BAH12040 AK314810 AL540315 AV726282 BC031790 AAH31790 BI669304 BP195204 BX464346 BX647887 DA155307 DA158596 DA365141 DA522334 DA523686 DA533318 DQ891785 ABM82711 DQ894969 ABM85895 M64930 AAA36491 NM_001271899 NP_001258828 NM_001271900 NP_001258829 NM_001271948 NP_001258877 NM_181674 NP_858060 NM_181675 NP_858061 NM_181676 NP_858062 NM_181677 NP_858063 NM_181678 NP_858064 NR_073526 NR_073527 |
| Function | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity). Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance (By similarity). {ECO:0000250}. |
| Subcellular Location | Isoform 1: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Membrane {ECO:0000250}. |
| Tissue Specificity | Brain. |
| Top Pathways | Dopaminergic synapse, mRNA surveillance pathway, PI3K-Akt signaling pathway, Hepatitis C, Hippo signaling pathway |
PP2A-B55-β siRNA (h) - sc-39187 from Santa Cruz Biotechnology
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PP2A-B55-β shRNA Plasmid (h) - sc-39187-SH from Santa Cruz Biotechnology
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PP2A-B55-β shRNA (h) Lentiviral Particles - sc-39187-V from Santa Cruz Biotechnology
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PP2A-B55-α/β/γ siRNA (h) - sc-44034 from Santa Cruz Biotechnology
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PP2A-B55-α/β/γ shRNA Plasmid (h) - sc-44034-SH from Santa Cruz Biotechnology
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PP2A-B55-α/β/γ shRNA (h) Lentiviral Particles - sc-44034-V from Santa Cruz Biotechnology
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PPP2R2B RNAi - H00005521-R02 from Novus Biologicals
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PPP2R2B RNAi - H00005521-R05 from Novus Biologicals
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PPP2R2B RNAi - H00005521-R06 from Novus Biologicals
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PPP2R2B RNAi - H00005521-R01 from Novus Biologicals
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PPP2R2B RNAi - H00005521-R04 from Novus Biologicals
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PPP2R2B RNAi - H00005521-R03 from Novus Biologicals
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MISSION® esiRNA - EHU079041 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0618 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0616 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0617 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP1036 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP1035 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17292 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17292 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04302 from Sigma-Aldrich
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PPP2R2B siRNA (Human) - CRH3700 from Cohesion Biosciences
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shRNA set against Human PPP2R2B (NM_181678.2) - SHH381396 from Creative biogene
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shRNA set against Human PPP2R2B(NM_004576.2) - SHR134416 from Creative biogene
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PPP2R2B shRNA Plasmid (Human) - CHH3700 from Cohesion Biosciences
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