| Gene Symbol |
ST18
|
| Entrez Gene |
9705
|
| Alt Symbol |
NZF3, ZC2HC10, ZNF387
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
suppression of tumorigenicity 18, zinc finger
|
| Other Description |
neural zinc finger transcription factor 3|suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)|suppression of tumorigenicity 18 protein|zinc finger protein 387
|
| Swissprots |
O60284 Q17RY1
|
| Accessions |
EAW86715 EAW86716 EAW86717 O60284 AB011107 BAA25461 AK311188 BC025662 BC026316 BC031075 BC117147 AAI17148 BC117149 AAI17150 BC143871 BC143872 BC143873 BC143875 BQ639545 DA288225 XM_006716487 XP_006716550 XM_011517629 XP_011515931 XM_011517630 XP_011515932 XM_011517631 XP_011515933 XM_011517632 XP_011515934 XM_011517633 XP_011515935 XM_011517634 XP_011515936 XM_011517635 XP_011515937 XM_011517636 XP_011515938 XM_011517637 XP_011515939 XM_011517638 XP_011515940 XM_011517639 XP_011515941 XM_011517640 XP_011515942 XM_011517641 XP_011515943 XM_011517642 XP_011515944 NM_014682 NP_055497
|
| Function |
Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity). Inhibits colony formation in cultured breast cancer cells. {ECO:0000250, ECO:0000269|PubMed:15489893}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15489893}.
|
| Tissue Specificity |
Detected at low levels in heart, liver, kidney, skeletal muscle, pancreas, testis, ovary and prostate. Detected at even lower levels in mammary epithelial cells and breast cancer cells. {ECO:0000269|PubMed:15489893}.
|