| Gene Symbol | Atg16l1 |
|---|---|
| Entrez Gene | 77040 |
| Alt Symbol | 1500009K01Rik, Apg16l, Atg16l, WDR30 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | autophagy related 16-like 1 (S. cerevisiae) |
| Other Description | APG16-like 1|Atg16L1 gamma|autophagy-related 16-like 1 gamma|autophagy-related protein 16-1 |
| Swissprots | Q80Y53 Q80U97 Q8C0J2 Q9DB63 Q80U99 Q80U98 Q6KAT7 |
| Accessions | EDL40144 EDL40145 EDL40146 EDL40147 EDL40148 Q8C0J2 AB087879 BAC55090 AB087880 BAC55091 AB087881 BAC55092 AB476646 BAL42358 AK005181 BAB23866 AK030983 BAC27201 AK048873 AK131120 BAD21370 AK134333 AK145673 AK155358 BAE33214 AK163246 BAE37254 AK170073 BAE41546 AK202676 AK218161 BC033362 BC049122 AAH49122 BC052087 BE988512 XM_006529950 XP_006530013 XR_387198 NM_001205391 NP_001192320 NM_001205392 NP_001192321 NM_029846 NP_084122 |
| Function | Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane. {ECO:0000269|PubMed:12665549, ECO:0000269|PubMed:24553140, ECO:0000269|PubMed:24954904}. |
| Subcellular Location | Cytoplasm. Preautophagosomal structure membrane {ECO:0000269|PubMed:24954904}; Peripheral membrane protein {ECO:0000305}. Note=Recruited to omegasomes membranes by WIPI2. Omegasomes are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures. Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5. Localizes also to discrete punctae along the ciliary axoneme. {ECO:0000269|PubMed:24954904}. |
| Tissue Specificity | Widely expressed. In the liver, isoform 2 is highly expressed and isoform 1 is weakly expressed. Isoform 3 is expressed in the brain. {ECO:0000269|PubMed:12665549}. |
| Top Pathways | Regulation of autophagy |
Atg16 CRISPR/Cas9 KO Plasmid (m) - sc-429488 from Santa Cruz Biotechnology
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Atg16 HDR Plasmid (m) - sc-429488-HDR from Santa Cruz Biotechnology
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Atg16 Double Nickase Plasmid (m) - sc-429488-NIC from Santa Cruz Biotechnology
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Atg16 Double Nickase Plasmid (m2) - sc-429488-NIC-2 from Santa Cruz Biotechnology
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Atg16 CRISPR Activation Plasmid (m) - sc-429488-ACT from Santa Cruz Biotechnology
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Atg16 CRISPR Activation Plasmid (m2) - sc-429488-ACT-2 from Santa Cruz Biotechnology
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Atg16 Lentiviral Activation Particles (m) - sc-429488-LAC from Santa Cruz Biotechnology
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Atg16 Lentiviral Activation Particles (m2) - sc-429488-LAC-2 from Santa Cruz Biotechnology
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Atg16 siRNA (m) - sc-72581 from Santa Cruz Biotechnology
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Atg16 shRNA Plasmid (m) - sc-72581-SH from Santa Cruz Biotechnology
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Atg16 shRNA (m) Lentiviral Particles - sc-72581-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU066111 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN27148 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND27148 from Sigma-Aldrich
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ATG16L1 siRNA (Mouse) - CRM9779 from Cohesion Biosciences
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ATG16L1 - MBS8200492 from MyBioSource
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Atg16 CRISPR/Cas9 KO Plasmid (m2) - sc-429488-KO-2 from Santa Cruz Biotechnology
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Atg16 HDR Plasmid (m2) - sc-429488-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Mouse ATG16L1 (NM_029846.4) - SHH242066 from Creative biogene
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Mouse ATG16L1 siRNA - orb289255 from Biorbyt
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ATG16L1 shRNA Plasmid (Mouse) - CHM9779 from Cohesion Biosciences
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