Gene Symbol |
ILF2
|
Entrez Gene |
3608
|
Alt Symbol |
NF45, PRO3063
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
interleukin enhancer binding factor 2
|
Other Description |
interleukin enhancer binding factor 2, 45kD|interleukin enhancer binding factor 2, 45kDa|interleukin enhancer-binding factor 2|nuclear factor of activated T-cells, 45-kDa
|
Swissprots |
Q9BWD4 Q9P1N0 Q12905 A6NDB0 Q5SR11 Q5SR10 B2R8G7 Q7L7R3
|
Accessions |
AAM45141 CAI18796 EAW53285 EAW53286 Q12905 AK223326 BAD97046 AK302214 BAG63571 AK310615 AK313364 BAG36164 BC000382 AAH00382 BM800544 BX450311 DC412988 DQ891378 ABM82304 DQ894555 ABM85481 HQ322261 AEE02016 HQ322262 AEE02017 U10323 AAA20993 NM_001267809 NP_001254738 NM_004515 NP_004506
|
Function |
Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. {ECO:0000269|PubMed:10574923, ECO:0000269|PubMed:11739746, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:9442054}.
|
Subcellular Location |
Nucleus, nucleolus. Cytoplasm. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
|