POLB

Gene Symbol POLB
Entrez Gene 5423
Alt Symbol -
Species Human
Gene Type protein-coding
Description polymerase (DNA directed), beta
Other Description DNA pol beta|DNA polymerase beta|DNA polymerase beta subunit|mutant DNA polymerase beta
Swissprots Q3KP48 P06746 B2RC78 Q6FI34
Accessions AAA60134 AAB37517 AAB37518 AAB60688 AAL91594 CAA48603 EAW63221 P06746 AK223537 BAD97257 AK294025 BAH11651 AK314976 BAG37475 BC100288 AAI00289 BC106909 AAI06910 BM678092 BP370570 CR536503 CAG38741 CR541802 CAG46601 D29013 BAA06099 JQ664683 AFI72772 JQ927442 L11607 AAB59441 M13140 AAA60133 S69873 AAD14051 XM_005273535 XP_005273592 XM_005273536 XP_005273593 XM_005273537 XP_005273594 XM_005273538 XP_005273595 XM_005273539 XP_005273596 XM_005273540 XP_005273597 XM_006716353 XP_006716416 XR_428311 NM_002690 NP_002681
Function Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. {ECO:0000269|PubMed:11805079, ECO:0000269|PubMed:21362556, ECO:0000269|PubMed:9207062, ECO:0000269|PubMed:9572863}.
Subcellular Location Nucleus. Cytoplasm. Note=Cytoplasmic in normal conditions. Translocates to the nucleus following DNA damage.
Top Pathways Base excision repair, HTLV-I infection, Viral carcinogenesis

DNA pol β siRNA (h) - sc-37773 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DNA pol β shRNA Plasmid (h) - sc-37773-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DNA pol β shRNA (h) Lentiviral Particles - sc-37773-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU160321 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17088 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17088 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01378 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr01378

POLB siRNA (Human) - CRH3626 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human POLB (NM_002690.2) - SHH379080 from Creative biogene

Category siRNA
Species Reactivities Human

POLB shRNA Plasmid (Human) - CHH3626 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

POLB miRNA 3'UTR clone - MiUTR3H-01788 from Creative biogene

Species Reactivities Human
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