POLB

Gene Symbol	POLB
Entrez Gene	5423
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	polymerase (DNA directed), beta
Other Description	DNA pol beta|DNA polymerase beta|DNA polymerase beta subunit|mutant DNA polymerase beta
Swissprots	Q3KP48 P06746 B2RC78 Q6FI34
Accessions	AAA60134 AAB37517 AAB37518 AAB60688 AAL91594 CAA48603 EAW63221 P06746 AK223537 BAD97257 AK294025 BAH11651 AK314976 BAG37475 BC100288 AAI00289 BC106909 AAI06910 BM678092 BP370570 CR536503 CAG38741 CR541802 CAG46601 D29013 BAA06099 JQ664683 AFI72772 JQ927442 L11607 AAB59441 M13140 AAA60133 S69873 AAD14051 XM_005273535 XP_005273592 XM_005273536 XP_005273593 XM_005273537 XP_005273594 XM_005273538 XP_005273595 XM_005273539 XP_005273596 XM_005273540 XP_005273597 XM_006716353 XP_006716416 XR_428311 NM_002690 NP_002681
Function	Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. {ECO:0000269|PubMed:11805079, ECO:0000269|PubMed:21362556, ECO:0000269|PubMed:9207062, ECO:0000269|PubMed:9572863}.
Subcellular Location	Nucleus. Cytoplasm. Note=Cytoplasmic in normal conditions. Translocates to the nucleus following DNA damage.
Top Pathways	Base excision repair, HTLV-I infection, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active rat DNA Polymerase beta full length protein - ab123225 from Abcam Category Protein Prices $242.00 Sizes 20 µg Source E. coli Species Rat

Human DNA Polymerase beta (mono methyl R151) peptide - ab39687 from Abcam Category Peptide

Human DNA Polymerase beta full length protein - ab111641 from Abcam Category Protein Source E. coli Species Human

Human DNA Polymerase beta full length protein - ab196082 from Abcam Category Protein Source E. coli Species Human

Human DNA Polymerase beta peptide - ab46818 from Abcam Category Peptide

POLB Protein Lysate (APL10735) - APL10735 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

POLB protein (His tag) - 80R-1949 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

DNA Polymerase beta Blocking Peptide - abx063101 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken

DNA polymerase beta (1-335, His-tag) - AR39132PU-L from Acris Antibodies Category Protein Prices $785.00 Sizes 500 µg Source E. coli Species Human

DNA polymerase beta (1-335, His-tag) - AR39132PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

DNA polymerase beta - H00005423-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

DNA polymerase beta - H00005423-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

DNA polymerase beta - H00005423-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DNA polymerase beta - H00005423-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DNA Polymerase beta, Human, Recombinant - 19-C159 from ARP American Research Products Category Protein Prices $119.00 Sizes 10 µg Source E. coli Species Human

POLB, 1-335aa, Human, His tag, E.coli - 01-P1190 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

POLB fusion protein - Ag12496 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

POLB Human - ENPS-175 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human POLB Enzyme - BP001666-C159 from Syd Labs Category Protein Prices $126.00, $378.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli-derived. Species Human

Recombinant Human POLB Enzyme - BP001666-ENZ-168 from Syd Labs Category Protein Prices $160.00, $2,700.00 Sizes 20 µg, 1 mg Source E. coli-derived. Species Human

POLB, 1-335aa, Recombinant Protein - GWB-P0848C from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human POLB, His-tagged - POLB-1014H from Creative Biomart Category Protein

Recombinant Human Polymerase (DNA Directed), Beta - POLB-620H from Creative Biomart Category Protein Source E. coli.

Recombinant Human POLB, His-tagged - POLB-28361TH from Creative Biomart Category Protein Source E. coli

Recombinant Human POLB, His-tagged - POLB-1827H from Creative Biomart Category Protein Source E.coli Species Human

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