| Gene Symbol |
GSPT1
|
| Entrez Gene |
2935
|
| Alt Symbol |
551G9.2, ETF3A, GST1, eRF3a
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
G1 to S phase transition 1
|
| Other Description |
G1 to S phase transition protein 1 homolog|eukaryotic peptide chain release factor GTP-binding subunit ERF3A|eukaryotic peptide chain release factor subunit 3a
|
| Swissprots |
J3KQG6 Q96GF2 P15170
|
| Accessions |
AAB67250 EAW85130 EAW85131 EAW85132 P15170 AK095367 AK095483 AK096386 AK290382 BAF83071 AK315267 BAG37683 AU132091 BC008391 BC009503 AAH09503 BM666324 BT006722 AAP35368 DC384910 X17644 CAA35635 NM_001130006 NP_001123478 NM_001130007 NP_001123479 NM_002094 NP_002085
|
| Function |
Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.
|
| Top Pathways |
mRNA surveillance pathway
|