Gene Symbol | GSPT1 |
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Entrez Gene | 2935 |
Alt Symbol | 551G9.2, ETF3A, GST1, eRF3a |
Species | Human |
Gene Type | protein-coding |
Description | G1 to S phase transition 1 |
Other Description | G1 to S phase transition protein 1 homolog|eukaryotic peptide chain release factor GTP-binding subunit ERF3A|eukaryotic peptide chain release factor subunit 3a |
Swissprots | J3KQG6 Q96GF2 P15170 |
Accessions | AAB67250 EAW85130 EAW85131 EAW85132 P15170 AK095367 AK095483 AK096386 AK290382 BAF83071 AK315267 BAG37683 AU132091 BC008391 BC009503 AAH09503 BM666324 BT006722 AAP35368 DC384910 X17644 CAA35635 NM_001130006 NP_001123478 NM_001130007 NP_001123479 NM_002094 NP_002085 |
Function | Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. |
Top Pathways | mRNA surveillance pathway |
eRF3a CRISPR/Cas9 KO Plasmid (h) - sc-404748 from Santa Cruz Biotechnology
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eRF3a HDR Plasmid (h) - sc-404748-HDR from Santa Cruz Biotechnology
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eRF3a Double Nickase Plasmid (h) - sc-404748-NIC from Santa Cruz Biotechnology
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eRF3a Double Nickase Plasmid (h2) - sc-404748-NIC-2 from Santa Cruz Biotechnology
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eRF3a CRISPR Activation Plasmid (h) - sc-404748-ACT from Santa Cruz Biotechnology
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eRF3a CRISPR Activation Plasmid (h2) - sc-404748-ACT-2 from Santa Cruz Biotechnology
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eRF3a Lentiviral Activation Particles (h) - sc-404748-LAC from Santa Cruz Biotechnology
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eRF3a Lentiviral Activation Particles (h2) - sc-404748-LAC-2 from Santa Cruz Biotechnology
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eRF3a siRNA (h) - sc-93210 from Santa Cruz Biotechnology
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eRF3a shRNA Plasmid (h) - sc-93210-SH from Santa Cruz Biotechnology
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eRF3a shRNA (h) Lentiviral Particles - sc-93210-V from Santa Cruz Biotechnology
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GSPT1 RNAi - H00002935-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN9727 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9727 from Sigma-Aldrich
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GSPT1 siRNA (Human) - CRH1983 from Cohesion Biosciences
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GSPT1 - MBS8230011 from MyBioSource
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eRF3a CRISPR/Cas9 KO Plasmid (h2) - sc-404748-KO-2 from Santa Cruz Biotechnology
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eRF3a HDR Plasmid (h2) - sc-404748-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human GSPT1 (NM_002094.3) - SHH308494 from Creative biogene
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Human GSPT1 siRNA - orb262485 from Biorbyt
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GSPT1 shRNA Plasmid (Human) - CHH1983 from Cohesion Biosciences
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GSPT1 miRNA 3'UTR clone - MiUTR4H-TG04016 from Creative biogene
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