| Gene Symbol |
CHPF2
|
| Entrez Gene |
54480
|
| Alt Symbol |
CSGLCA-T, CSGlcAT, ChSy-3, chPF-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chondroitin polymerizing factor 2
|
| Other Description |
N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase|chondroitin sulfate glucuronyltransferase|chondroitin synthase-3
|
| Swissprots |
Q6UXD2 Q6P2I4 B2DBD8 Q9P2E5
|
| Accessions |
EAL24509 EAW54010 EAW54011 EAW54012 Q9P2E5 AB037823 BAA92640 AB095812 BAG30817 AI191668 AK025885 AK025897 AK056331 BAG51678 AY358407 AAQ88773 BC052944 BC064509 AAH64509 NM_001284295 NP_001271224 NM_019015 NP_061888
|
| Function |
Transfers glucuronic acid (GlcUA) from UDP-GlcUA to N- acetylgalactosamine residues on the non-reducing end of the elongating chondroitin polymer. Has no N- acetylgalactosaminyltransferase activity. {ECO:0000269|PubMed:12145278, ECO:0000269|PubMed:18316376}.
|
| Subcellular Location |
Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Ubiquitous. Highly expressed in placenta, small intestine and pancreas. {ECO:0000269|PubMed:12145278}.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
|