Gene Symbol | CHPF2 |
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Entrez Gene | 54480 |
Alt Symbol | CSGLCA-T, CSGlcAT, ChSy-3, chPF-2 |
Species | Human |
Gene Type | protein-coding |
Description | chondroitin polymerizing factor 2 |
Other Description | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase|chondroitin sulfate glucuronyltransferase|chondroitin synthase-3 |
Swissprots | Q6UXD2 Q6P2I4 B2DBD8 Q9P2E5 |
Accessions | EAL24509 EAW54010 EAW54011 EAW54012 Q9P2E5 AB037823 BAA92640 AB095812 BAG30817 AI191668 AK025885 AK025897 AK056331 BAG51678 AY358407 AAQ88773 BC052944 BC064509 AAH64509 NM_001284295 NP_001271224 NM_019015 NP_061888 |
Function | Transfers glucuronic acid (GlcUA) from UDP-GlcUA to N- acetylgalactosamine residues on the non-reducing end of the elongating chondroitin polymer. Has no N- acetylgalactosaminyltransferase activity. {ECO:0000269|PubMed:12145278, ECO:0000269|PubMed:18316376}. |
Subcellular Location | Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
Tissue Specificity | Ubiquitous. Highly expressed in placenta, small intestine and pancreas. {ECO:0000269|PubMed:12145278}. |
Top Pathways | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate |
CSGlcA-T CRISPR/Cas9 KO Plasmid (h) - sc-412288 from Santa Cruz Biotechnology
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CSGlcA-T HDR Plasmid (h) - sc-412288-HDR from Santa Cruz Biotechnology
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CSGlcA-T Double Nickase Plasmid (h) - sc-412288-NIC from Santa Cruz Biotechnology
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CSGlcA-T Double Nickase Plasmid (h2) - sc-412288-NIC-2 from Santa Cruz Biotechnology
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CSGlcA-T CRISPR Activation Plasmid (h) - sc-412288-ACT from Santa Cruz Biotechnology
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CSGlcA-T CRISPR Activation Plasmid (h2) - sc-412288-ACT-2 from Santa Cruz Biotechnology
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CSGlcA-T Lentiviral Activation Particles (h) - sc-412288-LAC from Santa Cruz Biotechnology
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CSGlcA-T Lentiviral Activation Particles (h2) - sc-412288-LAC-2 from Santa Cruz Biotechnology
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CSGlcA-T siRNA (h) - sc-89564 from Santa Cruz Biotechnology
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CSGlcA-T shRNA Plasmid (h) - sc-89564-SH from Santa Cruz Biotechnology
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CSGlcA-T shRNA (h) Lentiviral Particles - sc-89564-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU021221 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6085 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6085 from Sigma-Aldrich
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CHPF2 siRNA (Human) - CRJ0086 from Cohesion Biosciences
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CHPF2 - MBS8202111 from MyBioSource
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shRNA set against Human CHPF2 (NM_019015.1) - SHH263357 from Creative biogene
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shRNA set against Human CSGlcA-T(NM_019015.1) - SHG202687 from Creative biogene
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CHPF2 shRNA Plasmid (Human) - CHJ0086 from Cohesion Biosciences
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CHPF2 miRNA 3'UTR clone - MiUTR1H-02461 from Creative biogene
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