Gene Symbol | AMBP |
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Entrez Gene | 259 |
Alt Symbol | A1M, EDC1, HCP, HI30, IATIL, ITI, ITIL, ITILC, UTI |
Species | Human |
Gene Type | protein-coding |
Description | alpha-1-microglobulin/bikunin precursor |
Other Description | bikunin|complex-forming glycoprotein heterogeneous in charge|growth-inhibiting protein 19|inter-alpha-trypsin inhibitor light chain|protein AMBP|protein HC|trypstatin|uristatin|uronic-acid-rich protein |
Swissprots | P00977 Q9UDI8 Q9UC58 P78491 Q5TBD7 Q2TU33 P02759 P02760 |
Accessions | AAA59196 CAA37726 CAA38585 CAA38586 CAA38587 CAJ44933 CBF57586 EAW87404 P02760 AK290837 BAF83526 AK303795 BAH14052 AK310776 AK310791 AY544123 AAT11154 BC041593 AAH41593 CB141734 HQ448440 ADQ32920 M11562 AAA59194 X04225 CAA27803 X04494 CAA28182 NM_001633 NP_001624 |
Function | Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization. {ECO:0000269|PubMed:7676539}. |
Subcellular Location | Secreted. |
Tissue Specificity | Expressed by the liver and secreted in plasma. Alpha-1-microglobulin occurs in many physiological fluids including plasma, urine, and cerebrospinal fluid. Inter-alpha- trypsin inhibitor is present in plasma and urine. |
AMBP CRISPR/Cas9 KO Plasmid (h) - sc-403136 from Santa Cruz Biotechnology
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AMBP HDR Plasmid (h) - sc-403136-HDR from Santa Cruz Biotechnology
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AMBP Double Nickase Plasmid (h) - sc-403136-NIC from Santa Cruz Biotechnology
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AMBP Double Nickase Plasmid (h2) - sc-403136-NIC-2 from Santa Cruz Biotechnology
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AMBP CRISPR Activation Plasmid (h) - sc-403136-ACT from Santa Cruz Biotechnology
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AMBP CRISPR Activation Plasmid (h2) - sc-403136-ACT-2 from Santa Cruz Biotechnology
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AMBP Lentiviral Activation Particles (h) - sc-403136-LAC from Santa Cruz Biotechnology
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AMBP Lentiviral Activation Particles (h2) - sc-403136-LAC-2 from Santa Cruz Biotechnology
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AMBP siRNA (h) - sc-39552 from Santa Cruz Biotechnology
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Bikunin shRNA Plasmid (h) - sc-39552-SH from Santa Cruz Biotechnology
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Bikunin shRNA (h) Lentiviral Particles - sc-39552-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU018891 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3103 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3103 from Sigma-Aldrich
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AMBP siRNA (Human) - CRH0178 from Cohesion Biosciences
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alpha 1-Microglobulin RNAi - H00000259-R01 from Novus Biologicals
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AMBP - MBS8233109 from MyBioSource
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shRNA set against Human AMBP (NM_001633.3) - SHH235646 from Creative biogene
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Human AMBP siRNA - orb260680 from Biorbyt
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AMBP shRNA Plasmid (Human) - CHH0178 from Cohesion Biosciences
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AMBP miRNA 3'UTR clone - MiUTR3H-01872 from Creative biogene
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