| Gene Symbol |
LYPD3
|
| Entrez Gene |
27076
|
| Alt Symbol |
C4.4A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
LY6/PLAUR domain containing 3
|
| Other Description |
2310061G07Rik|GPI-anchored metastasis-associated protein C4.4A homolog|GPI-anchored metastasis-associated protein homolog|MIG-C4|ly6/PLAUR domain-containing protein 3|matrigel-induced gene C4 protein
|
| Swissprots |
Q9UJ74 O95274
|
| Accessions |
AAG09062 EAW57190 O95274 AF082889 AAD13751 AJ223603 CAA11469 AK075464 BAG52146 AK290905 BAF83594 AK314773 BAG37310 AL832153 CAI46120 AY359006 AAQ89365 BC039167 AAH39167 BC041061 BP367221 DA837818 HQ447474 ADQ31960 NM_014400 NP_055215
|
| Function |
Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression. {ECO:0000269|PubMed:11179665, ECO:0000269|PubMed:11245483, ECO:0000269|PubMed:12592373, ECO:0000269|PubMed:15012588}.
|
| Subcellular Location |
Cell membrane; Lipid-anchor, GPI-anchor.
|
| Tissue Specificity |
Expressed in placenta, skin and urothelium. Found in suprabasal keratinocytes of chronic wounds. Weak expression is found in esophagus and peripheral blood mononuclear cells. Found in the majority of primary and metastatic transitional cell carcinomas (TCCs) and as well in breast cancer tissues, but not in adjacent normal tissues. High expression is found in the tumor component of some noninvasive superficial lesions and in invasive and metastatic urothelial cancers. {ECO:0000269|PubMed:11179665, ECO:0000269|PubMed:12592373, ECO:0000269|PubMed:15012588}.
|
