Gene Symbol | PPAPDC1B |
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Entrez Gene | 84513 |
Alt Symbol | DPPL1, HTPAP |
Species | Human |
Gene Type | protein-coding |
Description | phosphatidic acid phosphatase type 2 domain containing 1B |
Other Description | diacylglycerol pyrophosphate like 1|phosphatidate phosphatase PPAPDC1B|phosphatidic acid phosphatase type 2 domain-containing protein 1B |
Swissprots | C9JKF5 Q8NEB5 Q9BY45 Q3KQX6 |
Accessions | EAW63325 EAW63326 EAW63327 EAW63328 EAW63329 Q8NEB5 AA761242 AF212238 AAK14924 AK292118 BAF84807 BC033025 AAH33025 BC106014 AAI06015 BE856962 BQ272061 DB458595 HQ447359 ADQ31845 XM_005273661 XP_005273718 XM_005273663 XP_005273720 XM_011544670 XP_011542972 XM_011544671 XP_011542973 XM_011544672 XP_011542974 XM_011544673 XP_011542975 XM_011544674 XP_011542976 XM_011544675 XP_011542977 XR_949491 XR_949492 XR_949493 NM_001102559 NP_001096029 NM_001102560 NP_001096030 NM_032483 NP_115872 |
Function | Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. May be a metastatic suppressor for hepatocellular carcinoma. {ECO:0000269|PubMed:16261160, ECO:0000269|PubMed:17590538}. |
Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:17590538}. |
HTPAP CRISPR/Cas9 KO Plasmid (h) - sc-413653 from Santa Cruz Biotechnology
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HTPAP HDR Plasmid (h) - sc-413653-HDR from Santa Cruz Biotechnology
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HTPAP Double Nickase Plasmid (h) - sc-413653-NIC from Santa Cruz Biotechnology
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HTPAP Double Nickase Plasmid (h2) - sc-413653-NIC-2 from Santa Cruz Biotechnology
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HTPAP CRISPR Activation Plasmid (h) - sc-413653-ACT from Santa Cruz Biotechnology
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HTPAP CRISPR Activation Plasmid (h2) - sc-413653-ACT-2 from Santa Cruz Biotechnology
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HTPAP Lentiviral Activation Particles (h) - sc-413653-LAC from Santa Cruz Biotechnology
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HTPAP Lentiviral Activation Particles (h2) - sc-413653-LAC-2 from Santa Cruz Biotechnology
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HTPAP siRNA (h) - sc-77623 from Santa Cruz Biotechnology
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HTPAP shRNA Plasmid (h) - sc-77623-SH from Santa Cruz Biotechnology
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HTPAP shRNA (h) Lentiviral Particles - sc-77623-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU075311 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0997 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0449 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP1000 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0450 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0999 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0996 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0998 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0448 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17200 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17200 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00904 from Sigma-Aldrich
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PPAPDC1B siRNA (Human) - CRJ3499 from Cohesion Biosciences
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shRNA set against Human PPAPDC1B (NM_032483.3) - SHH380288 from Creative biogene
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