Gene Symbol | KIF18A |
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Entrez Gene | 81930 |
Alt Symbol | MS-KIF18A, PPP1R99 |
Species | Human |
Gene Type | protein-coding |
Description | kinesin family member 18A |
Other Description | kinesin-like protein KIF18A|protein phosphatase 1, regulatory subunit 99 |
Swissprots | Q4VPE3 Q9H0F3 Q86VS5 Q8NI77 |
Accessions | EAW68271 Q8NI77 AB062483 BAB93508 AK093850 AK312576 BAG35470 AL136819 CAB66753 AM393105 CAL37983 AW770226 AY791349 AAX16185 BC026090 AAH26090 BC035917 BC048347 AAH48347 DB080843 NM_031217 NP_112494 |
Function | Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. {ECO:0000269|PubMed:17346968, ECO:0000269|PubMed:18267093, ECO:0000269|PubMed:18513970, ECO:0000269|PubMed:19625775}. |
Subcellular Location | Cell projection, ruffle. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. |
KIF18A CRISPR/Cas9 KO Plasmid (h) - sc-406899 from Santa Cruz Biotechnology
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KIF18A HDR Plasmid (h) - sc-406899-HDR from Santa Cruz Biotechnology
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KIF18A Double Nickase Plasmid (h) - sc-406899-NIC from Santa Cruz Biotechnology
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KIF18A Double Nickase Plasmid (h2) - sc-406899-NIC-2 from Santa Cruz Biotechnology
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KIF18A CRISPR Activation Plasmid (h) - sc-406899-ACT from Santa Cruz Biotechnology
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KIF18A CRISPR Activation Plasmid (h2) - sc-406899-ACT-2 from Santa Cruz Biotechnology
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KIF18A Lentiviral Activation Particles (h) - sc-406899-LAC from Santa Cruz Biotechnology
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KIF18A Lentiviral Activation Particles (h2) - sc-406899-LAC-2 from Santa Cruz Biotechnology
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KIF18A siRNA (h) - sc-96629 from Santa Cruz Biotechnology
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KIF18A shRNA Plasmid (h) - sc-96629-SH from Santa Cruz Biotechnology
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KIF18A shRNA (h) Lentiviral Particles - sc-96629-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU028041 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11179 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11179 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05086 from Sigma-Aldrich
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KIF18A siRNA (Human) - CRJ3086 from Cohesion Biosciences
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shRNA set against Human KIF18A (NM_031217.3) - SHH325043 from Creative biogene
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shRNA set against Human KIF18A(NM_031217.3) - SHL196428 from Creative biogene
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KIF18A shRNA Plasmid (Human) - CHJ3086 from Cohesion Biosciences
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KIF18A miRNA 3'UTR clone - MiUTR1H-05306 from Creative biogene
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