Gene Symbol | TMEM8B |
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Entrez Gene | 51754 |
Alt Symbol | C9orf127, NAG-5, NGX6 |
Species | Human |
Gene Type | protein-coding |
Description | transmembrane protein 8B |
Other Description | Protein NGX6|nasopharyngeal carcinoma expressed 6|nasopharyngeal carcinoma related protein|nasopharyngeal carcinoma-associated gene 6 protein|protein NAG-5 |
Swissprots | Q49AB1 Q4KMX5 Q9HBY2 A6NDV4 O75539 Q9P0U7 Q5TCW5 B3KQF3 |
Accessions | A6NDV4 CAF86955 EAW58325 EAW58326 EAW58327 EAW58328 AF070572 AAC28644 AF188239 AAG29055 AK074844 BAG52015 BC041377 BC043384 BC064951 BC082765 BC098265 AAH98265 BC098296 AAH98296 BC099733 AAH99733 XM_005251483 XP_005251540 XM_011517901 XP_011516203 XM_011517902 XP_011516204 XM_011517903 XP_011516205 XM_011517904 XP_011516206 XM_011517905 XP_011516207 XM_011517906 XP_011516208 XM_011517907 XP_011516209 XM_011517908 XP_011516210 XM_011517909 XP_011516211 XM_011517910 XP_011516212 XM_011517911 XP_011516213 XM_011517912 XP_011516214 XM_011517913 XP_011516215 XM_011517914 XP_011516216 XM_011517915 XP_011516217 XM_011517916 XP_011516218 XM_011517917 XP_011516219 XM_011517918 XP_011516220 XM_011517919 XP_011516221 NM_001042589 NP_001036054 NM_001042590 NP_001036055 NM_016446 NP_057530 |
Function | May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion. {ECO:0000269|PubMed:15498789, ECO:0000269|PubMed:15723283, ECO:0000269|PubMed:17270023, ECO:0000269|PubMed:17641538}. |
Subcellular Location | Isoform 2: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. Mitochondrion. Endoplasmic reticulum. Note=Also detected in mitochondrion and endoplasmic reticulum. |
NGX6 CRISPR/Cas9 KO Plasmid (h) - sc-409428 from Santa Cruz Biotechnology
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NGX6 HDR Plasmid (h) - sc-409428-HDR from Santa Cruz Biotechnology
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NGX6 Double Nickase Plasmid (h) - sc-409428-NIC from Santa Cruz Biotechnology
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NGX6 Double Nickase Plasmid (h2) - sc-409428-NIC-2 from Santa Cruz Biotechnology
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NGX6 CRISPR Activation Plasmid (h) - sc-409428-ACT from Santa Cruz Biotechnology
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NGX6 CRISPR Activation Plasmid (h2) - sc-409428-ACT-2 from Santa Cruz Biotechnology
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NGX6 Lentiviral Activation Particles (h) - sc-409428-LAC from Santa Cruz Biotechnology
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NGX6 Lentiviral Activation Particles (h2) - sc-409428-LAC-2 from Santa Cruz Biotechnology
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NGX6 siRNA (h) - sc-92697 from Santa Cruz Biotechnology
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NGX6 shRNA Plasmid (h) - sc-92697-SH from Santa Cruz Biotechnology
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NGX6 shRNA (h) Lentiviral Particles - sc-92697-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU086121 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21679 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21679 from Sigma-Aldrich
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TMEM8B siRNA (Human) - CRH9934 from Cohesion Biosciences
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TMEM8B - MBS8239558 from MyBioSource
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shRNA set against Human TMEM8B (NM_016446.3) - SHH431124 from Creative biogene
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shRNA set against Human C9orf127(NM_016446.3) - SHG129715 from Creative biogene
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Human TMEM8B siRNA - orb270436 from Biorbyt
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TMEM8B shRNA Plasmid (Human) - CHH9934 from Cohesion Biosciences
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TMEM8B miRNA 3'UTR clone - MiUTR1H-01511 from Creative biogene
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TMEM8B miRNA 3'UTR clone - MiUTR3H-14230 from Creative biogene
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TMEM8B miRNA 3'UTR clone - MiUTR3H-14231 from Creative biogene
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