WWOX

Gene Symbol WWOX
Entrez Gene 51741
Alt Symbol D16S432E, EIEE28, FOR, FRA16D, HHCMA56, PRO0128, SCAR12, SDR41C1, WOX1
Species Human
Gene Type protein-coding
Description WW domain containing oxidoreductase
Other Description WW domain-containing oxidoreductase|WW domain-containing protein WWOX|fragile site FRA16D oxidoreductase|short chain dehydrogenase/reductase family 41C member 1|short chain dehydrogenase/reductase family 41C, member 1
Swissprots Q9NRF4 Q96RF2 Q9NRF6 Q9NPC9 Q9NZC7 Q96KM3 Q5MYT5 A8K323 Q9NRF5 Q9NRK1 Q9BTT8 Q9NZC5
Accessions AAF27050 AAL05449 AAL05450 AAL05451 EAW95579 EAW95580 Q9NZC7 AF187015 AAF31694 AF211943 AAF27049 AF227526 AAF82053 AF227527 AAF82054 AF227528 AAF82055 AF227529 AAF82056 AF239665 AF395123 AAK81727 AF395124 AAK81728 AK027626 BAG51361 AK290438 BAF83127 AK291300 BAF83989 AK298322 BAG60575 AW874692 AW874693 AY256821 AAP94227 BC003184 AAH03184 BT007445 AAP36113 BU157392 DB035405 U13395 AAA21465 XM_006721195 XP_006721258 XM_011523100 XP_011521402 XM_011523101 XP_011521403 XM_011523102 XP_011521404 XM_011523103 XP_011521405 XM_011523104 XP_011521406 XM_011523105 XP_011521407 NM_001291997 NP_001278926 NM_016373 NP_057457 NM_130791 NP_570607 NR_120435 NR_120436 NM_018560 NM_130788 NM_130790 NM_130792 NM_130844
Function Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm. {ECO:0000250, ECO:0000269|PubMed:11719429, ECO:0000269|PubMed:15070730, ECO:0000269|PubMed:15548692, ECO:0000269|PubMed:16061658, ECO:0000269|PubMed:16219768, ECO:0000269|PubMed:19366691, ECO:0000269|PubMed:19465938}.
Subcellular Location Cytoplasm. Nucleus. Mitochondrion. Golgi apparatus. Note=Partially localizes to the mitochondria. Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Translocates to the nucleus in response to TGFB1. Isoform 5 and isoform 6 may localize in the nucleus. {ECO:0000250}.
Tissue Specificity Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines. {ECO:0000269|PubMed:10786676, ECO:0000269|PubMed:11719429}.

WWOX Antibody - 4045 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, mock transfected or transfected with mouse WWOX, and from MCF-7 and rat brain using WWOX Antibody.

WWOX (A-5) - sc-373846 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
WWOX (A-5): sc-373846. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

WWOX (C-7) - sc-374449 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
WWOX (C-7): sc-374449. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

WWOX (H-126) - sc-366157 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
WWOX (H-126): sc-366157. Western blot analysis of WWOX expression in mouse ovary tissue extract.

WWOX (N-19) - sc-20528 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
WWOX (N-19): sc-20528. Western blot analysis of WWOX expression in mouse ovary tissue extract.

WWOX (P-20) - sc-20529 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
WWOX (P-20): sc-20529. Western blot analysis of WWOX expression in mouse ovary tissue extract.

Anti-WWOX (phospho Y33) antibody - ab78210 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-WWOX (phospho Y33) antibody (ab78210) at 1/500 dilutionLane 1 : Extracts from HepG2 cells, treated with PMA (125ng/ml, 30mins)Lane 2 : Extracts from HepG2 cells, treated with PMA (125ng/ml, 30mins) plus 5µg immunizing peptideLysates/proteins at 5 µg per lane.

Anti-WWOX (phospho Y33) antibody - ab129881 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab129881, at 1/50 dilution, staining WWOX in paraffin-embedded Human colon carcinoma tissue by Immunohistochemistry, in the absence (left) and presence (right) of the phosphopeptide.

Anti-WWOX (phospho Y33) antibody - ab193624 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-WWOX (phospho Y33) antibody (ab193624) at 1/500 dilutionLane 1 : Extracts from HepG2 cells treated with PMALane 2 : Extracts from HepG2 cells treated with PMA with antigen specific peptide

Anti-WWOX antibody - ab69624 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-WWOX antibody (ab69624) at 1/500 dilutionLane 1 : Extracts from HepG2 cells with no immunizing peptideLane 2 : Extracts from HepG2 cells with immunizing peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-WWOX antibody - ab89128 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-WWOX antibody (ab89128) at 1 µg/ml + 293 cell lysate at 50 µgdeveloped using the ECL technique

Anti-WWOX antibody - ab174650 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of WWOX in Immunoprecipitates of Jurkat whole cell lysates (1 mg for IP, 20% of IP loaded) using ab174650 at 6 µg/mg lysate for IP (Lane 1). For WB detection an anti-WWOX antibody was used at 0.4 µg/ml. Lane 2 represents control IgG IP.

Anti-WWOX1 + 4 antibody - ab14691 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-WWOX2 antibody - ab14937 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-WWOX3 antibody - ab123722 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-WWOX3 antibody (ab123722) at 1/100 dilution + Mouse testis tissue lysate at 35 µg

Anti-WWOX Antibody (aa89-107) - LS-C40750 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-WWOX Antibody - LS-C83452 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-WWOX Antibody (aa89-107) - LS-C87146 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-WWOX Antibody (aa36-126) - LS-C144274 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-WWOX Antibody (aa369-396, AP) - LS-C224667 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WWOX Antibody (aa369-396, APC) - LS-C224668 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WWOX Antibody (aa369-396, Biotin) - LS-C224669 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WWOX Antibody (aa369-396, FITC) - LS-C224670 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WWOX Antibody (aa369-396, Azide-free, HRP) - LS-C224671 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WWOX Antibody (aa75-125) - LS-C290723 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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