WWOX

Gene Symbol	WWOX
Entrez Gene	51741
Alt Symbol	D16S432E, EIEE28, FOR, FRA16D, HHCMA56, PRO0128, SCAR12, SDR41C1, WOX1
Species	Human
Gene Type	protein-coding
Description	WW domain containing oxidoreductase
Other Description	WW domain-containing oxidoreductase|WW domain-containing protein WWOX|fragile site FRA16D oxidoreductase|short chain dehydrogenase/reductase family 41C member 1|short chain dehydrogenase/reductase family 41C, member 1
Swissprots	Q9NRF4 Q96RF2 Q9NRF6 Q9NPC9 Q9NZC7 Q96KM3 Q5MYT5 A8K323 Q9NRF5 Q9NRK1 Q9BTT8 Q9NZC5
Accessions	AAF27050 AAL05449 AAL05450 AAL05451 EAW95579 EAW95580 Q9NZC7 AF187015 AAF31694 AF211943 AAF27049 AF227526 AAF82053 AF227527 AAF82054 AF227528 AAF82055 AF227529 AAF82056 AF239665 AF395123 AAK81727 AF395124 AAK81728 AK027626 BAG51361 AK290438 BAF83127 AK291300 BAF83989 AK298322 BAG60575 AW874692 AW874693 AY256821 AAP94227 BC003184 AAH03184 BT007445 AAP36113 BU157392 DB035405 U13395 AAA21465 XM_006721195 XP_006721258 XM_011523100 XP_011521402 XM_011523101 XP_011521403 XM_011523102 XP_011521404 XM_011523103 XP_011521405 XM_011523104 XP_011521406 XM_011523105 XP_011521407 NM_001291997 NP_001278926 NM_016373 NP_057457 NM_130791 NP_570607 NR_120435 NR_120436 NM_018560 NM_130788 NM_130790 NM_130792 NM_130844
Function	Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm. {ECO:0000250, ECO:0000269|PubMed:11719429, ECO:0000269|PubMed:15070730, ECO:0000269|PubMed:15548692, ECO:0000269|PubMed:16061658, ECO:0000269|PubMed:16219768, ECO:0000269|PubMed:19366691, ECO:0000269|PubMed:19465938}.
Subcellular Location	Cytoplasm. Nucleus. Mitochondrion. Golgi apparatus. Note=Partially localizes to the mitochondria. Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Translocates to the nucleus in response to TGFB1. Isoform 5 and isoform 6 may localize in the nucleus. {ECO:0000250}.
Tissue Specificity	Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines. {ECO:0000269|PubMed:10786676, ECO:0000269|PubMed:11719429}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human WWOX full length protein - ab132490 from Abcam Category Protein Source Wheat germ Species Human

Human WWOX peptide - ab45233 from Abcam Category Peptide

Human WWOX protein fragment - ab86687 from Abcam Category Protein Source E. coli Species Human

WWOX Antibody Blocking Peptide - LS-E3591 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

WWOX Antibody Blocking Peptide - LS-E25169 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human WWOX Protein - NBC1-28766 from Novus Biologicals Category Protein Prices $269.00 Sizes 50 µg Source E.coli Species Human

WWOX Recombinant Protein - H00051741-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

WWOX-Antibody-Center-Y287-Blocking-Peptide - BP14312c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

WWOX-Antibody-C-term-Blocking-Peptide - BP14792b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

WWOX blocking peptide - GTX89427-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

WWOX Protein (OPPA01851) - OPPA01851 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Human WWOX protein - orb176091 from Biorbyt Category Protein Prices $349.00, $434.00 Sizes 2 μl, 10 μl

Human WW Domain Containing Oxidoreductase protein - orb90313 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E.coli

WWOX Blocking Peptide - 33R-10313 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

WWOX protein (His tag) - 80R-1157 from Fitzgerald Category Protein Prices $255.00 Sizes 50 µg Source E.coli

WWOX / FOR (1-234, His-tag) - AR09211PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 250 µg Source E. coli Species Human

WWOX / FOR (1-234, His-tag) - AR09211PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 50 µg Source E. coli Species Human

WWOX / FOR - H00051741-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

WWOX / FOR - H00051741-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

WWOX / FOR Control Peptide - AP10374CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

WWOX / FOR control peptide - AP10376CP-N from Acris Antibodies Category Peptide Prices $390.00 Sizes 100 µg

WWOX / FOR control peptide - AP10377CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 100 µg

WWOX1/4 Control Peptide - AP10375CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

WW Domain Containing Oxidoreductase, Human Recombinant - 228-11650-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

Recombinant Human WWOX - 228-11650-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

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