LDLRAD4

Gene Symbol LDLRAD4
Entrez Gene 753
Alt Symbol C18orf1
Species Human
Gene Type protein-coding
Description low density lipoprotein receptor class A domain containing 4
Other Description clone 22|low-density lipoprotein receptor class A domain-containing protein 4
Swissprots Q6NXP3 Q5U646 O15167 B3KNT9 E9PAY9 O15166 O15165 K7EN38 O15168
Accessions CCF76928 CCF76929 CCF76930 CCF76931 CCF76932 CCF76933 EAX01511 EAX01512 EAX01513 EAX01514 O15165 AA310737 AF009424 AAC52023 AF009425 AAC52024 AF009426 AAC52025 AF009427 AAC52026 AI668861 AI878844 AK023474 AK055028 BAG51451 AK291574 BAF84263 BC029958 BC030199 AAH30199 BC047093 BC066971 AAH66971 BM715555 BM805426 BM917439 BM991627 BX114947 CR748400 DA126127 DA246476 DA276009 DA321390 DA369876 DA391326 DA412541 DA418068 DB107684 DB272592 DC327672 DC328561 H04910 HQ447439 ADQ31925 HY115972 HY309264 N48737 N63974 XM_005258140 XP_005258197 XM_006722353 XP_006722416 XM_006722354 XP_006722417 XM_011525737 XP_011524039 XM_011525738 XP_011524040 XM_011525739 XP_011524041 XM_011525740 XP_011524042 NM_004338 NM_181483 NM_001003674 NP_001003674 NM_001003675 NP_001003675 NM_001276249 NP_001263178 NM_001276251 NP_001263180 NM_181481 NP_852146 NM_181482 NP_852147
Function Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal. {ECO:0000269|PubMed:24627487}.
Subcellular Location Early endosome membrane {ECO:0000269|PubMed:24627487}; Single-pass membrane protein {ECO:0000269|PubMed:24627487}.
Tissue Specificity Expressed in lymphocytes. {ECO:0000269|PubMed:19461657}.

LDLRAD4 (C-16) - sc-84715 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
C18orf1 (C-16): sc-84715. Western blot analysis of C18orf1 expression in non-transfected: sc-117752 (A) and mouse C18orf1 transfected: sc-118903 (B) 293T whole cell lysates.

LDLRAD4 (D-13) - sc-84716 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-C18orf1 antibody - ab72919 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-C18orf1 antibody (ab72919) at 1/500 dilutionLane 1 : C18orf1 transfected 293T lysateLane 2 : Non-transfected 293T lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilutionObserved band size : 34 kDa (why is the actual band size different from the predicted?)

Anti-C18orf1 antibody - ab118741 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-C18orf1 antibody (ab118741) at 1 µg/ml + Human fetal heart lysate at 10 µg

Anti-C18orf1 antibody - ab122994 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-C18orf1 antibody (ab122994) at 1 µg/ml + U937 cell lysate at 10 µg

Anti-LDLRAD4 / C18orf1 Antibody - LS-C308739 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-LDLRAD4 / C18orf1 Antibody (aa176-225) - LS-C145793 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
C18orf1 antibody LS-C145793 Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml.

Anti-LDLRAD4 / C18orf1 Antibody (C-Terminus) - LS-C146009 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
C18orf1 antibody LS-C146009 Western blot of U937 Cell lysate. Antibody concentration 1 ug/ml.

LDLRAD4 Antibody - NBP2-38061 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: LDLRAD4 Antibody [NBP2-38061] - Staining of human lymph node shows moderate nuclear positivity in germinal center cells and non-germinal center cells.

LDLRAD4 Antibody - H00000753-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: LDLRAD4 Antibody [H00000753-B01P] - Analysis of C18orf1 expression in transfected 293T cell line by C18orf1 polyclonal antibody. Lane1:C18orf1 transfected lysate(33.66 KDa). Lane2:Non-transfected lysate.

C18orf1 Polyclonal Antibody - bs-9652R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-C18ORF1 antibody produced in rabbit - SAB2107708 from Sigma-Aldrich

Prices $341.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-C18ORF1: <B>Cat. No. SAB2107708</B>: Western blot analysis of C18orf1 in U937 with C18orf1 (chromosome 18 open reading frame 1) antibody against the C terminal of C18orf1 (50 μg) antibody at 1.0 μg/mL.

Anti-C18ORF1 antibody produced in mouse - SAB1405538 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-C18orf1: <B>Cat. No. SAB1405538</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~33.7 kDa using C18orf1 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-C18ORF1 antibody produced in rabbit - SAB2107709 from Sigma-Aldrich

Prices $341.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-C18ORF1: <B>Cat. No. SAB2107709</B>: Western blot analysis of C18orf1 in Fetal Heart with C18orf1 (chromosome 18 open reading frame 1) antibody against the C terminal of C18orf1 (50 μg) antibody at 1.0 μg/mL.

C18orf1 antibody - C-terminal region (ARP62431_P050) - ARP62431_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

C18orf1 antibody - C-terminal region (ARP62432_P050) - ARP62432_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

C18orf1 antibody - H00000753-B01P from Acris Antibodies

Prices $360.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot analysis of C18orf1 expression in transfected 293T cell line (H00000753-T01) by C18orf1 MaxPab polyclonal antibody. Lane1:C18orf1 transfected lysate(33.66 KDa). Lane2:Non-transfected lysate.

C18orf1 Antibody - GWB-MW584H from Genway Biotech

Prices $368.00
Sizes 50 µg
Host Rabbit

C18orf1 Antibody - GWB-MW585I from Genway Biotech

Prices $368.00
Sizes 50 µg
Host Rabbit

LDLRAD4, Polyclonal Antibody - MBS6012259 from MyBioSource

Prices $580.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Rabbit anti-Human C18orf1 polyclonal antibody - DPABH-11268 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-C18ORF1 (aa 181-230) polyclonal antibody - DPABH-21238 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-C18ORF1 monoclonal antibody - DCABH-14773 from Creative Diagnostics

Host Rabbit
Clonality Monoclonal

C18orf1 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-9652R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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