| Gene Symbol |
LDLRAD4
|
| Entrez Gene |
753
|
| Alt Symbol |
C18orf1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
low density lipoprotein receptor class A domain containing 4
|
| Other Description |
clone 22|low-density lipoprotein receptor class A domain-containing protein 4
|
| Swissprots |
Q6NXP3 Q5U646 O15167 B3KNT9 E9PAY9 O15166 O15165 K7EN38 O15168
|
| Accessions |
CCF76928 CCF76929 CCF76930 CCF76931 CCF76932 CCF76933 EAX01511 EAX01512 EAX01513 EAX01514 O15165 AA310737 AF009424 AAC52023 AF009425 AAC52024 AF009426 AAC52025 AF009427 AAC52026 AI668861 AI878844 AK023474 AK055028 BAG51451 AK291574 BAF84263 BC029958 BC030199 AAH30199 BC047093 BC066971 AAH66971 BM715555 BM805426 BM917439 BM991627 BX114947 CR748400 DA126127 DA246476 DA276009 DA321390 DA369876 DA391326 DA412541 DA418068 DB107684 DB272592 DC327672 DC328561 H04910 HQ447439 ADQ31925 HY115972 HY309264 N48737 N63974 XM_005258140 XP_005258197 XM_006722353 XP_006722416 XM_006722354 XP_006722417 XM_011525737 XP_011524039 XM_011525738 XP_011524040 XM_011525739 XP_011524041 XM_011525740 XP_011524042 NM_004338 NM_181483 NM_001003674 NP_001003674 NM_001003675 NP_001003675 NM_001276249 NP_001263178 NM_001276251 NP_001263180 NM_181481 NP_852146 NM_181482 NP_852147
|
| Function |
Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal. {ECO:0000269|PubMed:24627487}.
|
| Subcellular Location |
Early endosome membrane {ECO:0000269|PubMed:24627487}; Single-pass membrane protein {ECO:0000269|PubMed:24627487}.
|
| Tissue Specificity |
Expressed in lymphocytes. {ECO:0000269|PubMed:19461657}.
|