| Gene Symbol | IRS1 |
|---|---|
| Entrez Gene | 3667 |
| Alt Symbol | HIRS-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | insulin receptor substrate 1 |
| Other Description | IRS-1 |
| Swissprots | P35568 |
| Accessions | AAB21608 AGG19175 AGG19176 AGG19177 AHG12642 AHG12643 AHG12644 CAD79961 CBL64020 EAW70838 EAW70839 P35568 AW469017 BC053895 AAH53895 EU831611 ACE87211 EU831698 ACE86532 S62539 AAB27175 NM_005544 NP_005535 |
| Function | May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). {ECO:0000250}. |
| Top Pathways | AMPK signaling pathway, cGMP-PKG signaling pathway, Non-alcoholic fatty liver disease (NAFLD), MicroRNAs in cancer, PI3K-Akt signaling pathway |