IRS1

Gene Symbol	IRS1
Entrez Gene	3667
Alt Symbol	HIRS-1
Species	Human
Gene Type	protein-coding
Description	insulin receptor substrate 1
Other Description	IRS-1
Swissprots	P35568
Accessions	AAB21608 AGG19175 AGG19176 AGG19177 AHG12642 AHG12643 AHG12644 CAD79961 CBL64020 EAW70838 EAW70839 P35568 AW469017 BC053895 AAH53895 EU831611 ACE87211 EU831698 ACE86532 S62539 AAB27175 NM_005544 NP_005535
Function	May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). {ECO:0000250}.
Top Pathways	AMPK signaling pathway, cGMP-PKG signaling pathway, Non-alcoholic fatty liver disease (NAFLD), MicroRNAs in cancer, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IRS-1 CRISPR/Cas9 KO Plasmid (h) - sc-400096 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IRS-1 HDR Plasmid (h) - sc-400096-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IRS-1 Double Nickase Plasmid (h) - sc-400096-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IRS-1 Double Nickase Plasmid (h2) - sc-400096-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IRS-1 CRISPR Activation Plasmid (h) - sc-400096-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IRS-1 CRISPR Activation Plasmid (h2) - sc-400096-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IRS-1 Lentiviral Activation Particles (h) - sc-400096-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IRS-1 Lentiviral Activation Particles (h2) - sc-400096-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IRS-1 siRNA (h) - sc-29376 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IRS-1 shRNA Plasmid (h) - sc-29376-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IRS-1 shRNA (h) Lentiviral Particles - sc-29376-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IRS-1 siRNA (h2) - sc-44268 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IRS-1 shRNA Plasmid (h2) - sc-44268-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IRS-1 shRNA (h2) Lentiviral Particles - sc-44268-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU020331 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® esiRNA - EHU033961 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10774 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10774 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07968 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr07968

IRS1 siRNA (Human) - CRH2459 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

IRS1 - MBS8206574 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human IRS1 (NM_005544.2) - SHH320753 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human IRS1(NM_005544.2) - SHL173784 from Creative biogene Category siRNA Species Reactivities Human

Human IRS1 siRNA - orb262961 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

IRS1 shRNA Plasmid (Human) - CHH2459 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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