SHANK2

Gene Symbol	SHANK2
Entrez Gene	22941
Alt Symbol	AUTS17, CORTBP1, CTTNBP1, ProSAP1, SHANK, SPANK-3
Species	Human
Gene Type	protein-coding
Description	SH3 and multiple ankyrin repeat domains 2
Other Description	GKAP/SAPAP interacting protein|SH3 and multiple ankyrin repeat domains protein 2|cortactin SH3 domain-binding protein|cortactin-binding protein 1|proline-rich synapse associated protein 1|proline-rich synapse-associated protein 1
Swissprots	Q9UPX8 Q3Y8G9 Q52LK2 Q9UKP1 C0SPG9 C0SPG8
Accessions	AFO66269 AFO66270 EAW74771 EAW74772 EAW74773 EAW74774 EAW74775 EAW74776 EAW74777 EAW74778 EAW74779 Q9UPX8 AA464273 AB028945 BAA82974 AB208025 BAH37016 AB208026 BAH37017 AB208027 BAH37018 AF131790 AF141901 AAF02496 AK095088 AK096045 AK128563 BC041371 BC093885 AAH93885 BC112097 AAI12098 BC113876 BC114484 AAI14485 BC143389 AAI43390 BC168372 AAI68372 BX648718 CV313099 DQ152234 AAZ77790 XM_005277930 XP_005277987 XM_005277932 XP_005277989 XM_006718478 XP_006718541 XM_011544854 XP_011543156 XM_011544855 XP_011543157 XM_011544856 XP_011543158 XM_011544857 XP_011543159 XM_011544858 XP_011543160 XM_011544859 XP_011543161 NM_012309 NP_036441 NM_133266 NP_573573 NR_110766
Function	Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
Subcellular Location	Apical cell membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Colocalizes with cortactin in growth cones in differentiating hippocampal neurons. Colocalized with PDE4D to the apical membrane of colonic crypt cells (By similarity). {ECO:0000250}.
Tissue Specificity	Isoform 3 is present in epithelial colonic cells (at protein level). {ECO:0000269|PubMed:16293618, ECO:0000269|PubMed:17244609}.
Top Pathways	Glutamatergic synapse

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SHANK2 / SHANK Antibody Blocking Peptide - LS-E1936 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SHANK2 / SHANK Antibody Blocking Peptide - LS-E23358 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SHANK2 / SHANK Antibody Blocking Peptide - LS-E23359 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SHANK2 Partial Recombinant Protein - H00022941-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SHANK2-Antibody-Center-Blocking-peptide - BP12783c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SHANK2 peptide - orb218419 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human

SHANK2 Blocking Peptide - abx063750 from Abbexa Category Peptide Species Human

SHANK2 - H00022941-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SHANK2 - H00022941-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SHANK2 Blocking Peptide - CBP2556 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

Recombinant Human SH3 and multiple ankyrin repeat domains protein 2(SHANK2) ,partial - CSB-YP892492HU CSB-EP892492HU CSB-BP892492HU CSB-MP892492HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SHANK2 Recombinant Protein Antigen - NBP1-85505PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SHANK2 Peptide, Human - M34GP14192H from Creative Peptides Category Peptide Source Synthetic. Species Human

SH3 and multiple ankyrin repeat domains protein 2 (SHANK2), partial, Recombinant Protein - MBS1448566 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

SHANK2 fusion protein - Ag26114 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

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