SHANK2
| Gene Symbol | SHANK2 |
|---|---|
| Entrez Gene | 22941 |
| Alt Symbol | AUTS17, CORTBP1, CTTNBP1, ProSAP1, SHANK, SPANK-3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | SH3 and multiple ankyrin repeat domains 2 |
| Other Description | GKAP/SAPAP interacting protein|SH3 and multiple ankyrin repeat domains protein 2|cortactin SH3 domain-binding protein|cortactin-binding protein 1|proline-rich synapse associated protein 1|proline-rich synapse-associated protein 1 |
| Swissprots | Q9UPX8 Q3Y8G9 Q52LK2 Q9UKP1 C0SPG9 C0SPG8 |
| Accessions | AFO66269 AFO66270 EAW74771 EAW74772 EAW74773 EAW74774 EAW74775 EAW74776 EAW74777 EAW74778 EAW74779 Q9UPX8 AA464273 AB028945 BAA82974 AB208025 BAH37016 AB208026 BAH37017 AB208027 BAH37018 AF131790 AF141901 AAF02496 AK095088 AK096045 AK128563 BC041371 BC093885 AAH93885 BC112097 AAI12098 BC113876 BC114484 AAI14485 BC143389 AAI43390 BC168372 AAI68372 BX648718 CV313099 DQ152234 AAZ77790 XM_005277930 XP_005277987 XM_005277932 XP_005277989 XM_006718478 XP_006718541 XM_011544854 XP_011543156 XM_011544855 XP_011543157 XM_011544856 XP_011543158 XM_011544857 XP_011543159 XM_011544858 XP_011543160 XM_011544859 XP_011543161 NM_012309 NP_036441 NM_133266 NP_573573 NR_110766 |
| Function | Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. |
| Subcellular Location | Apical cell membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Colocalizes with cortactin in growth cones in differentiating hippocampal neurons. Colocalized with PDE4D to the apical membrane of colonic crypt cells (By similarity). {ECO:0000250}. |
| Tissue Specificity | Isoform 3 is present in epithelial colonic cells (at protein level). {ECO:0000269|PubMed:16293618, ECO:0000269|PubMed:17244609}. |
| Top Pathways | Glutamatergic synapse |
Shank 2 CRISPR/Cas9 KO Plasmid (h) - sc-403143 from Santa Cruz Biotechnology
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Shank 2 HDR Plasmid (h) - sc-403143-HDR from Santa Cruz Biotechnology
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Shank 2 Double Nickase Plasmid (h) - sc-403143-NIC from Santa Cruz Biotechnology
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Shank 2 Double Nickase Plasmid (h2) - sc-403143-NIC-2 from Santa Cruz Biotechnology
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Shank 2 CRISPR Activation Plasmid (h) - sc-403143-ACT from Santa Cruz Biotechnology
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Shank 2 CRISPR Activation Plasmid (h2) - sc-403143-ACT-2 from Santa Cruz Biotechnology
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Shank 2 Lentiviral Activation Particles (h) - sc-403143-LAC from Santa Cruz Biotechnology
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Shank 2 Lentiviral Activation Particles (h2) - sc-403143-LAC-2 from Santa Cruz Biotechnology
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Shank 2 siRNA (h) - sc-42198 from Santa Cruz Biotechnology
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Shank 2 shRNA Plasmid (h) - sc-42198-SH from Santa Cruz Biotechnology
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Shank 2 shRNA (h) Lentiviral Particles - sc-42198-V from Santa Cruz Biotechnology
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SHANK2 RNAi - H00022941-R02 from Novus Biologicals
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MISSION® esiRNA - EHU152721 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19285 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19285 from Sigma-Aldrich
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SHANK2 siRNA (Human) - CRH7889 from Cohesion Biosciences
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SHANK2 RNAi - H00022941-R01 from Novus Biologicals
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SHANK2 - MBS8217300 from MyBioSource
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shRNA set against Human SHANK2 (NM_133266.3) - SHH406912 from Creative biogene
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Human SHANK2 siRNA - orb268391 from Biorbyt
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SHANK2 shRNA Plasmid (Human) - CHH7889 from Cohesion Biosciences
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