Gene Symbol | GIF |
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Entrez Gene | 2694 |
Alt Symbol | IF, IFMH, INF, TCN3 |
Species | Human |
Gene Type | protein-coding |
Description | gastric intrinsic factor (vitamin B synthesis) |
Other Description | gastric intrinsic factor|intrinsic factor |
Swissprots | B4DVZ1 P27352 B2RAN8 |
Accessions | EAW73860 P27352 AK301290 BAG62848 AK301295 BAG62853 AK314275 BAG36935 BC037958 AAH37958 DQ892469 ABM83395 DQ895682 ABM86608 X76562 CAA54061 XM_011544939 XP_011543241 NM_005142 NP_005133 |
Function | Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated endocytosis. |
Subcellular Location | Secreted. |
Tissue Specificity | Gastric mucosa. |
Top Pathways | Vitamin digestion and absorption |
GIF CRISPR/Cas9 KO Plasmid (h) - sc-406117 from Santa Cruz Biotechnology
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GIF HDR Plasmid (h) - sc-406117-HDR from Santa Cruz Biotechnology
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GIF Double Nickase Plasmid (h) - sc-406117-NIC from Santa Cruz Biotechnology
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GIF Double Nickase Plasmid (h2) - sc-406117-NIC-2 from Santa Cruz Biotechnology
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GIF CRISPR Activation Plasmid (h) - sc-406117-ACT from Santa Cruz Biotechnology
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GIF CRISPR Activation Plasmid (h2) - sc-406117-ACT-2 from Santa Cruz Biotechnology
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GIF Lentiviral Activation Particles (h) - sc-406117-LAC from Santa Cruz Biotechnology
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GIF Lentiviral Activation Particles (h2) - sc-406117-LAC-2 from Santa Cruz Biotechnology
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GIF siRNA (h) - sc-97044 from Santa Cruz Biotechnology
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GIF shRNA Plasmid (h) - sc-97044-SH from Santa Cruz Biotechnology
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GIF shRNA (h) Lentiviral Particles - sc-97044-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU136261 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9279 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9279 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00797 from Sigma-Aldrich
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GIF siRNA (Human) - CRH1797 from Cohesion Biosciences
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GIF - MBS8203247 from MyBioSource
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shRNA set against Human GIF (NM_005142.2) - SHH301014 from Creative biogene
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shRNA set against Human GIF(NM_005142.2) - SHH084305 from Creative biogene
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GIF shRNA Plasmid (Human) - CHH1797 from Cohesion Biosciences
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GIF miRNA 3'UTR clone - MiUTR1H-04032 from Creative biogene
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