Gene Symbol | NPBWR1 |
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Entrez Gene | 2831 |
Alt Symbol | GPR7 |
Species | Human |
Gene Type | protein-coding |
Description | neuropeptides B/W receptor 1 |
Other Description | G protein-coupled receptor 7|G-protein coupled receptor 7|neuropeptide B/W receptor 1|neuropeptides B/W receptor type 1|opioid-somatostatin-like receptor 7 |
Swissprots | Q6NTC7 P48145 |
Accessions | AAC50197 AFF59482 EAW86722 P48145 BC069117 AAH69117 BC107101 AAI07102 NM_005285 NP_005276 |
Function | Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Found in cerebellum and frontal cortex. Detected at high levels in hippocampus, amygdala and trachea; at moderate levels in fetal brain, pituitary gland and prostate. Not in caudate, accumbens, kidney or liver. Also detected at high levels in lung carcinoma. {ECO:0000269|PubMed:12401809}. |
Top Pathways | Neuroactive ligand-receptor interaction |
GPR7 CRISPR/Cas9 KO Plasmid (h) - sc-408131 from Santa Cruz Biotechnology
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GPR7 HDR Plasmid (h) - sc-408131-HDR from Santa Cruz Biotechnology
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GPR7 Double Nickase Plasmid (h) - sc-408131-NIC from Santa Cruz Biotechnology
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GPR7 Double Nickase Plasmid (h2) - sc-408131-NIC-2 from Santa Cruz Biotechnology
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GPR7 CRISPR Activation Plasmid (h) - sc-408131-ACT from Santa Cruz Biotechnology
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GPR7 CRISPR Activation Plasmid (h2) - sc-408131-ACT-2 from Santa Cruz Biotechnology
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GPR7 Lentiviral Activation Particles (h) - sc-408131-LAC from Santa Cruz Biotechnology
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GPR7 Lentiviral Activation Particles (h2) - sc-408131-LAC-2 from Santa Cruz Biotechnology
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GPR7 siRNA (h) - sc-106740 from Santa Cruz Biotechnology
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GPR7 shRNA Plasmid (h) - sc-106740-SH from Santa Cruz Biotechnology
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GPR7 shRNA (h) Lentiviral Particles - sc-106740-V from Santa Cruz Biotechnology
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NPBWR1 RNAi - H00002831-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN15440 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15440 from Sigma-Aldrich
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NPBWR1 siRNA (Human) - CRH1896 from Cohesion Biosciences
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shRNA set against Human NPBWR1 (NM_005285.3) - SHH354076 from Creative biogene
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Human NPBWR1 siRNA - orb262398 from Biorbyt
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NPBWR1 shRNA Plasmid (Human) - CHH1896 from Cohesion Biosciences
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NPBWR1 miRNA 3'UTR clone - MiUTR1H-06870 from Creative biogene
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