| Gene Symbol | HDAC1 |
|---|---|
| Entrez Gene | 3065 |
| Alt Symbol | GON-10, HD1, RPD3, RPD3L1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | histone deacetylase 1 |
| Other Description | reduced potassium dependency, yeast homolog-like 1 |
| Swissprots | Q92534 Q13547 |
| Accessions | BAG70921 EAX07540 EAX07541 Q13547 AB451297 BAG70111 AB451430 BAG70244 AK225555 AK296308 BAH12310 AK299241 BAG61272 AK299792 BAG61671 AK313061 AY627042 AAT44863 BC000301 AAH00301 BX648055 CAI46269 CR541717 CAG46518 D50405 BAA08909 DQ891398 ABM82324 DQ894577 ABM85503 U50079 AAC50475 XM_011541309 XP_011539611 NM_004964 NP_004955 |
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A |
| Subcellular Location | Nucleus. |
| Tissue Specificity | Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain. |
| Top Pathways | Notch signaling pathway, MicroRNAs in cancer, Alcoholism, Epstein-Barr virus infection, Viral carcinogenesis |