HDAC1

Gene Symbol	HDAC1
Entrez Gene	3065
Alt Symbol	GON-10, HD1, RPD3, RPD3L1
Species	Human
Gene Type	protein-coding
Description	histone deacetylase 1
Other Description	reduced potassium dependency, yeast homolog-like 1
Swissprots	Q92534 Q13547
Accessions	BAG70921 EAX07540 EAX07541 Q13547 AB451297 BAG70111 AB451430 BAG70244 AK225555 AK296308 BAH12310 AK299241 BAG61272 AK299792 BAG61671 AK313061 AY627042 AAT44863 BC000301 AAH00301 BX648055 CAI46269 CR541717 CAG46518 D50405 BAA08909 DQ891398 ABM82324 DQ894577 ABM85503 U50079 AAC50475 XM_011541309 XP_011539611 NM_004964 NP_004955
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A
Subcellular Location	Nucleus.
Tissue Specificity	Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.
Top Pathways	Notch signaling pathway, MicroRNAs in cancer, Alcoholism, Epstein-Barr virus infection, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Histone Deacetylase 1 (HDAC1) Human SimpleStep ELISA™ Kit - ab200012 from Abcam Category ELISA Kit Prices $470.00 Sizes 1 x 96 tests Sensitivity 0.35 ng/ml Range 1.25 ng/ml - 80 ng/ml

HDAC1 Sumoylation Assay Kit - ab115132 from Abcam Category Cellular Assay Prices $494.00, $659.00 Sizes 48 tests, 96 tests

Mouse/Human/Rat Phospho-HDAC1 (Ser421) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1298 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human/Rat HDAC1 ELISA Kit (Cell-Based ELISA) - LS-F2036 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Human HDAC1 ELISA Kit (Sandwich ELISA) - LS-F8215 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.059 ng/ml Range 0.156-10 ng/ml

Rat HDAC1 ELISA Kit (Sandwich ELISA) - LS-F8602 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.29 ng/ml Range 0.156-10 ng/ml

Mouse HDAC1 ELISA Kit (Sandwich ELISA) - LS-F8827 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.27 ng/ml Range 0.156-10 ng/ml

Mouse HDAC1 ELISA Kit (Sandwich ELISA) - LS-F11613 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.78 Range 0.156-10 ng/ml

Rat HDAC1 ELISA Kit (Sandwich ELISA) - LS-F11612 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.78 Range 0.156-10 ng/ml

HDAC1 Fluorometric Assay Kit - KA0789 from Novus Biologicals Category Assay Kit Prices $679.00 Sizes 1 kit

HDAC1 Colorimetric Assay Kit - KA0788 from Novus Biologicals Category Assay Kit Prices $599.00 Sizes 1 kit

HDAC Fluorometric Assay Kit - KA0787 from Novus Biologicals Category Assay Kit Prices $599.00 Sizes 1 kit

HDAC1 Colorimetric Assay Kit - KA0629 from Novus Biologicals Category Assay Kit Prices $799.00 Sizes 1 kit

HDAC1 Assay/Inhibitor Screening Assay Kit - KA1320 from Novus Biologicals Category Assay Kit Prices $519.00 Sizes 1 kit

Rabbit anti-HDAC1 Antibody, Affinity Purified - PLA0134 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Human Histone Deacetylase 1 ELISA Kit - abx151815 from Abbexa Category ELISA Kit Sensitivity 0.061 ng/ml Range 0.156 ng/ml - 10 ng/ml

Histone Deacetylase 1 (HDAC1), Human, ELISA Kit - SEC206Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.061ng/mL Range 0.156-10ng/mL

Histone deacetylase 1, HDAC1, Human, ELISA Kit - E0883h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Plectin (PLEC), Human, ELISA Kit - SEC754Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.115ng/mL Range 0.312-20ng/mL

HDAC1 (Human) IP-WB Antibody Pair - H00003065-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

HDAC1 ELISA Kit - KE00033 from Acris Antibodies Category ELISA Kit Prices $599.00 Sizes 1 kit Range 11 pg/ml

Human HDAC1 ELISA Kit - KE00033 from Proteintech Group Category ELISA Kit Prices $599.00 Sizes 1 Sensitivity 11 pg/mL Range 62.5pg/mL-4000pg/mL

Histone Deacetylase 1, ELISA Kit - MBS080924 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone Deacetylase 1, ELISA Kit - MBS047656 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone Deacetylase 1, ELISA Kit - MBS089385 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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