Gene Symbol | MARCH3 |
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Entrez Gene | 115123 |
Alt Symbol | MARCH-III, RNF173 |
Species | Human |
Gene Type | protein-coding |
Description | membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase |
Other Description | E3 ubiquitin-protein ligase MARCH3|RING finger protein 173|membrane-associated RING-CH protein III |
Swissprots | B9EJE7 A8K264 Q86UD3 |
Accessions | EAW48844 Q86UD3 AF055007 AK000103 AK290129 BAF82818 BC047569 AAH47569 BC146948 AAI46949 BC146964 AAI46965 BG719261 DB455278 XM_011543128 XP_011541430 XM_011543129 XP_011541431 XM_011543130 XP_011541432 XM_011543131 XP_011541433 XM_011543132 XP_011541434 XM_011543133 XP_011541435 XR_948234 NM_178450 NP_848545 |
Function | E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasmic vesicle membrane {ECO:0000269|PubMed:16428329}; Multi-pass membrane protein {ECO:0000269|PubMed:16428329}. Early endosome membrane {ECO:0000269|PubMed:16428329}; Multi-pass membrane protein {ECO:0000269|PubMed:16428329}. |
MARCH3 CRISPR/Cas9 KO Plasmid (h) - sc-409013 from Santa Cruz Biotechnology
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MARCH3 HDR Plasmid (h) - sc-409013-HDR from Santa Cruz Biotechnology
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MARCH3 Double Nickase Plasmid (h) - sc-409013-NIC from Santa Cruz Biotechnology
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MARCH3 Double Nickase Plasmid (h2) - sc-409013-NIC-2 from Santa Cruz Biotechnology
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MARCH3 CRISPR Activation Plasmid (h) - sc-409013-ACT from Santa Cruz Biotechnology
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MARCH3 CRISPR Activation Plasmid (h2) - sc-409013-ACT-2 from Santa Cruz Biotechnology
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MARCH3 Lentiviral Activation Particles (h) - sc-409013-LAC from Santa Cruz Biotechnology
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MARCH3 Lentiviral Activation Particles (h2) - sc-409013-LAC-2 from Santa Cruz Biotechnology
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MARCH3 siRNA (h) - sc-91851 from Santa Cruz Biotechnology
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MARCH3 shRNA Plasmid (h) - sc-91851-SH from Santa Cruz Biotechnology
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MARCH3 shRNA (h) Lentiviral Particles - sc-91851-V from Santa Cruz Biotechnology
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MARCH3 RNAi - H00115123-R01 from Novus Biologicals
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MISSION® esiRNA - EHU004921 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13032 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13032 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06597 from Sigma-Aldrich
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MARCH3 siRNA (Human) - CRJ4431 from Cohesion Biosciences
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shRNA set against Human MARCH3 (NM_178450.3) - SHH338267 from Creative biogene
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Human MARCH3 siRNA - orb274932 from Biorbyt
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MARCH3 shRNA Plasmid (Human) - CHJ4431 from Cohesion Biosciences
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MARCH3 miRNA 3'UTR clone - MiUTR4H-TG05366 from Creative biogene
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