Gene Symbol | BCDIN3D |
---|---|
Entrez Gene | 144233 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | BCDIN3 domain containing |
Other Description | BCDIN3 domain-containing protein|pre-miRNA 5'-monophosphate methyltransferase|probable methyltransferase BCDIN3D |
Swissprots | A8K829 Q7Z5W3 |
Accessions | EAW58101 Q7Z5W3 AK292194 BAF84883 BC040957 BC053560 AAH53560 BU622810 CD690663 HQ448096 ADQ32577 NM_181708 NP_859059 |
Function | O-methyltransferase that specifically dimethylates the 5' monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Able to mediate methylation of pre-miR-145, as well as other pre- miRNAs. {ECO:0000269|PubMed:23063121}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:23063121}. |