| Gene Symbol |
Bid
|
| Entrez Gene |
12122
|
| Alt Symbol |
2700049M22Rik, AI875481, AU022477
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
BH3 interacting domain death agonist
|
| Other Description |
BH3-interacting domain death agonist|p22 BID
|
| Swissprots |
P70444 Q99M39
|
| Accessions |
EDK99650 EDK99651 P70444 AK045731 BAC32475 AK051076 BAC34518 AK052356 BAC34955 AK077657 BAC36932 AK161235 BAE36258 AK177453 AK186625 BC002031 AAH02031 U75506 AAC71064 XM_006505409 XP_006505472 XM_006505410 XP_006505473 XM_006505411 XP_006505474 XM_006507120 XP_006507183 XM_006507121 XP_006507184 XM_011251467 XP_011249769 NM_007544 NP_031570
|
| Function |
Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c. {ECO:0000269|PubMed:9873064}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:9873064}. Mitochondrion membrane {ECO:0000269|PubMed:9873064}. Note=When uncleaved, it is predominantly cytoplasmic. p15 BID translocates to mitochondria as an integral membrane protein. p13 and p22 BID are associated with the mitochondrial membrane.
|
| Top Pathways |
Sphingolipid signaling pathway, Apoptosis, Non-alcoholic fatty liver disease (NAFLD), Tuberculosis, Amyotrophic lateral sclerosis (ALS)
|