Gene Symbol | Bid |
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Entrez Gene | 12122 |
Alt Symbol | 2700049M22Rik, AI875481, AU022477 |
Species | Mouse |
Gene Type | protein-coding |
Description | BH3 interacting domain death agonist |
Other Description | BH3-interacting domain death agonist|p22 BID |
Swissprots | P70444 Q99M39 |
Accessions | EDK99650 EDK99651 P70444 AK045731 BAC32475 AK051076 BAC34518 AK052356 BAC34955 AK077657 BAC36932 AK161235 BAE36258 AK177453 AK186625 BC002031 AAH02031 U75506 AAC71064 XM_006505409 XP_006505472 XM_006505410 XP_006505473 XM_006505411 XP_006505474 XM_006507120 XP_006507183 XM_006507121 XP_006507184 XM_011251467 XP_011249769 NM_007544 NP_031570 |
Function | Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c. {ECO:0000269|PubMed:9873064}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:9873064}. Mitochondrion membrane {ECO:0000269|PubMed:9873064}. Note=When uncleaved, it is predominantly cytoplasmic. p15 BID translocates to mitochondria as an integral membrane protein. p13 and p22 BID are associated with the mitochondrial membrane. |
Top Pathways | Sphingolipid signaling pathway, Apoptosis, Non-alcoholic fatty liver disease (NAFLD), Tuberculosis, Amyotrophic lateral sclerosis (ALS) |
BID CRISPR/Cas9 KO Plasmid (m) - sc-419329 from Santa Cruz Biotechnology
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BID HDR Plasmid (m) - sc-419329-HDR from Santa Cruz Biotechnology
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BID Double Nickase Plasmid (m) - sc-419329-NIC from Santa Cruz Biotechnology
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BID Double Nickase Plasmid (m2) - sc-419329-NIC-2 from Santa Cruz Biotechnology
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BID CRISPR Activation Plasmid (m) - sc-419329-ACT from Santa Cruz Biotechnology
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BID CRISPR Activation Plasmid (m2) - sc-419329-ACT-2 from Santa Cruz Biotechnology
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BID Lentiviral Activation Particles (m) - sc-419329-LAC from Santa Cruz Biotechnology
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BID Lentiviral Activation Particles (m2) - sc-419329-LAC-2 from Santa Cruz Biotechnology
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BID siRNA (m) - sc-29801 from Santa Cruz Biotechnology
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BID shRNA Plasmid (m) - sc-29801-SH from Santa Cruz Biotechnology
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BID shRNA (m) Lentiviral Particles - sc-29801-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU087401 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN27627 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND27627 from Sigma-Aldrich
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BID siRNA (Mouse) - CRM0380 from Cohesion Biosciences
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BID - MBS8223949 from MyBioSource
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shRNA set against Mouse BID (NM_007544.3) - SHH246694 from Creative biogene
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shRNA set against Mouse Bid(NM_007544.3) - SHG100657 from Creative biogene
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Mouse BID siRNA - orb279856 from Biorbyt
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BID shRNA Plasmid (Mouse) - CHM0380 from Cohesion Biosciences
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BID miRNA 3'UTR clone - MiUTR1M-02204 from Creative biogene
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