| Gene Symbol |
Vasp
|
| Entrez Gene |
22323
|
| Alt Symbol |
-
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
vasodilator-stimulated phosphoprotein
|
| Other Description |
-
|
| Swissprots |
Q3UDF1 Q3U0C2 Q3TCD2 Q91VD2 P70460 Q9R214 Q3TAP0
|
| Accessions |
CAA67108 EDL23127 EDL23128 EDL23129 EDL23130 EDL23131 EDL23132 EDL23133 P70460 AF084548 AAD16045 AK140329 BAE24338 AK150103 BAE29310 AK155480 AK157021 BAE33933 AK170780 BAE42025 AK171302 AK171715 BAE42628 AK217126 BB850928 BC010223 AAH10223 BC015289 AAH15289 CF582891 CO040918 NM_001282021 NP_001268950 NM_001282022 NP_001268951 NM_009499 NP_033525 NR_104069
|
| Function |
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin- bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:10660044}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10660044}. Cell junction, focal adhesion {ECO:0000269|PubMed:10660044}. Cell junction, tight junction {ECO:0000250}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:10660044}. Cell projection, filopodium membrane {ECO:0000269|PubMed:10660044}. Note=Targeted to stress fibers and focal adhesions through interaction with a number of proteins including MRL family members. Localizes to the plasma membrane in protruding lamellipodia and filopodial tips. Stimulation by thrombin or PMA, also translocates VASP to focal adhesions. Localized along the sides of actin filaments throughout the peripheral cytoplasm under basal conditions (By similarity). In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes) (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in thymus and spleen. Lower levels in lung, ovary, placenta and fat. {ECO:0000269|PubMed:10069337}.
|
| Top Pathways |
Focal adhesion, Leukocyte transendothelial migration, Fc gamma R-mediated phagocytosis, cGMP-PKG signaling pathway, Rap1 signaling pathway
|