Vasp

Gene Symbol Vasp
Entrez Gene 22323
Alt Symbol -
Species Mouse
Gene Type protein-coding
Description vasodilator-stimulated phosphoprotein
Other Description -
Swissprots Q3UDF1 Q3U0C2 Q3TCD2 Q91VD2 P70460 Q9R214 Q3TAP0
Accessions CAA67108 EDL23127 EDL23128 EDL23129 EDL23130 EDL23131 EDL23132 EDL23133 P70460 AF084548 AAD16045 AK140329 BAE24338 AK150103 BAE29310 AK155480 AK157021 BAE33933 AK170780 BAE42025 AK171302 AK171715 BAE42628 AK217126 BB850928 BC010223 AAH10223 BC015289 AAH15289 CF582891 CO040918 NM_001282021 NP_001268950 NM_001282022 NP_001268951 NM_009499 NP_033525 NR_104069
Function Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin- bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:10660044}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10660044}. Cell junction, focal adhesion {ECO:0000269|PubMed:10660044}. Cell junction, tight junction {ECO:0000250}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:10660044}. Cell projection, filopodium membrane {ECO:0000269|PubMed:10660044}. Note=Targeted to stress fibers and focal adhesions through interaction with a number of proteins including MRL family members. Localizes to the plasma membrane in protruding lamellipodia and filopodial tips. Stimulation by thrombin or PMA, also translocates VASP to focal adhesions. Localized along the sides of actin filaments throughout the peripheral cytoplasm under basal conditions (By similarity). In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes) (By similarity). {ECO:0000250}.
Tissue Specificity Highly expressed in thymus and spleen. Lower levels in lung, ovary, placenta and fat. {ECO:0000269|PubMed:10069337}.
Top Pathways Focal adhesion, Leukocyte transendothelial migration, Fc gamma R-mediated phagocytosis, cGMP-PKG signaling pathway, Rap1 signaling pathway

VASP CRISPR/Cas9 KO Plasmid (m) - sc-423654 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

VASP HDR Plasmid (m) - sc-423654-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

VASP Double Nickase Plasmid (m) - sc-423654-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

VASP Double Nickase Plasmid (m2) - sc-423654-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

VASP CRISPR Activation Plasmid (m) - sc-423654-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

VASP CRISPR Activation Plasmid (m2) - sc-423654-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

VASP Lentiviral Activation Particles (m) - sc-423654-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

VASP Lentiviral Activation Particles (m2) - sc-423654-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

VASP siRNA (m) - sc-36809 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

VASP shRNA Plasmid (m) - sc-36809-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

VASP shRNA (m) Lentiviral Particles - sc-36809-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU048811 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN44085 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND44085 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

VASP siRNA (Mouse) - CRM4374 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

VASP - MBS8207938 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse VASP (NM_009499.2) - SHH442324 from Creative biogene

Category siRNA
Species Reactivities Mouse

shRNA set against Mouse Vasp(NM_009499.2) - SHL121542 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse VASP siRNA - orb283850 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

VASP shRNA Plasmid (Mouse) - CHM4374 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse

VASP miRNA 3'UTR clone - MiUTR1M-12662 from Creative biogene

Species Reactivities Mouse
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