| Gene Symbol | CD59 |
|---|---|
| Entrez Gene | 966 |
| Alt Symbol | 16.3A5, 1F5, EJ16, EJ30, EL32, G344, HRF-20, HRF20, MAC-IP, MACIF, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD59 molecule, complement regulatory protein |
| Other Description | 1F5 antigen|20 kDa homologous restriction factor|CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344)|CD59 glycoprotein|Ly-6-like protein|MEM43 antigen|T cell-activating protein|human leukocyte antigen MIC11|lymphocytic antigen CD59/MEM43|membrane attack complex (MAC) inhibition factor|membrane attack complex inhibition factor|membrane inhibitor of reactive lysis|protectin|surface anitgen recognized by monoclonal antibody 16.3A5 |
| Swissprots | P13987 |
| Accessions | AAA88793 CAA78486 EAW68192 EAW68193 P13987 AI147924 AK128571 AK309894 AK311778 BAG34721 AL037045 AL049957 AL080087 AL703204 AU136899 AU139009 AU139541 AW166662 BC001506 AAH01506 BC033226 BE899630 BG284181 BI752924 BM457931 BM551313 BM680161 BM724931 BM829941 BM911556 BQ230563 BQ440441 BT007104 AAP35768 BU154979 BX475103 CF529941 CR407661 CAG28589 CR541722 CAG46523 DA250543 DA578905 DA840870 DA917093 DQ890640 ABM92257 DQ893818 ABM84744 EU176474 ABW03275 M27909 AAA60543 M34671 AAA51952 M95708 AAA60957 X16447 CAA34467 X17198 CAA35059 X84805 NM_000611 NP_000602 NM_001127223 NP_001120695 NM_001127225 NP_001120697 NM_001127226 NP_001120698 NM_001127227 NP_001120699 NM_203329 NP_976074 NM_203330 NP_976075 NM_203331 NP_976076 |
| Function | Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. |
| Subcellular Location | Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Soluble form found in a number of tissues. |
| Top Pathways | Complement and coagulation cascades, Hematopoietic cell lineage |