AURKB
| Gene Symbol | AURKB |
|---|---|
| Entrez Gene | 9212 |
| Alt Symbol | AIK2, AIM-1, AIM1, ARK2, AurB, IPL1, PPP1R48, STK12, STK5, aurkb-sv1, aurkb-sv2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | aurora kinase B |
| Other Description | ARK-2|STK-1|aurora 1|aurora kinase B-Sv1|aurora kinase B-Sv2|aurora- and Ipl1-like midbody-associated protein 1|aurora-1|aurora-B|aurora-related kinase 2|aurora/IPL1-related kinase 2|protein phosphatase 1, regulatory subunit 48|serine/threonine kinase 12|serine/threonine-protein kinase 12|serine/threonine-protein kinase 5|serine/threonine-protein kinase aurora-B |
| Swissprots | C7G534 Q96GD4 Q96DV5 C7G535 J9JID1 Q9UQ46 D3DTR4 O60446 B4DNM4 C7G533 O14630 O95083 |
| Accessions | CAF04021 EAW90073 EAW90074 EAW90075 EAW90076 EAW90077 EAW90078 EAW90079 Q96GD4 AB011446 BAA82709 AB011450 BAA32136 AB519677 BAI23190 AB519678 BAI23191 AB519679 BAI23192 AF004022 AAB65786 AF008552 AAC12709 AF015254 AAC98891 AK297976 BAG60286 AK314889 BAG37403 AY677083 BC000442 AAH00442 BC009751 AAH09751 BC013300 AAH13300 BC080581 AAH80581 BE514591 BP225027 BT019534 AAV38341 XM_011524070 XP_011522372 XM_011524071 XP_011522373 XM_011524072 XP_011522374 XR_934117 XR_934118 NM_001256834 NP_001243763 NM_001284526 NP_001271455 NM_004217 NP_004208 |
| Function | Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission- competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex |
| Subcellular Location | Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalized with gamma tubulin in the mid-body. Proper localization of the active, Thr-232- phosphorylated form during metaphase may be dependent upon interaction with SPDYC. Colocalized with SIRT2 during cytokinesis with the midbody. |
| Tissue Specificity | High level expression seen in the thymus. It is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. Expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase. {ECO:0000269|PubMed:9809983, ECO:0000269|PubMed:9858806}. |
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